Mouse Anti-GRAMD4 Recombinant Antibody (CBLG1-3205) (CBMAB-G4769-LY)

This product is antibody recognizes GRAMD4. The antibody CBLG1-3205 immunoassay techniques such as: WB.
See all GRAMD4 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBLG1-3205

Antibody Isotype

IgG

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

GRAMD4

Introduction

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]

Entrez Gene ID

23151

UniProt ID

Q6IC98

Alternative Names

GRAM Domain Containing 4; Death-Inducing-Protein; DIP; GRAM Domain-Containing Protein 4; Death-Inducing Protein; DA59H18.1; DJ439F8.1; KIAA0767;

Function

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177).

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity).

Biological Process

Apoptotic process Source: UniProtKB-KW
Negative regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB

Cellular Location

Mitochondrion membrane; Endoplasmic reticulum membrane. Colocalizes with COX4I1.

References

Xu, X., Liu, Y., Gao, J., Shi, X., Yan, Y., Yang, N., ... & Zhang, Q. (2023). GRAMD4 regulates PEDV-induced cell apoptosis inhibiting virus replication via the endoplasmic reticulum stress pathway. Veterinary Microbiology, 279, 109666.

Ge, Q. Y., Chen, J., Li, G. X., Tan, X. L., Song, J., Ning, D., ... & Zhang, B. X. (2021). GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma. Clinical and Translational Medicine, 11(11), e635.

Besprozvannaya, M., Dickson, E., Li, H., Ginburg, K. S., Bers, D. M., Auwerx, J., & Nunnari, J. (2018). GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Elife, 7, e31019.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-GRAMD4 Recombinant Antibody (CBLG1-3205)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote

Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: