Mouse Anti-GRAMD4 Recombinant Antibody (CBFYH-3474) (V2LY-0226-LY1024)

Name: Mouse Anti-GRAMD4 Recombinant Antibody (CBFYH-3474)
SKU: V2LY-0226-LY1024
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-3474

Application

ELISA, IP, IF, WB

Immunogen

Amino acids 470-570 mapping near the C-terminus of human GRAMD4.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GRAMD4

Entrez Gene ID

23151

UniProt ID

Q6IC98

Function

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177).

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity).

Biological Process

Apoptotic process Source: UniProtKB-KW
Negative regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB

Cellular Location

Mitochondrion membrane; Endoplasmic reticulum membrane. Colocalizes with COX4I1.

Xu, X., Liu, Y., Gao, J., Shi, X., Yan, Y., Yang, N., ... & Zhang, Q. (2023). GRAMD4 regulates PEDV-induced cell apoptosis inhibiting virus replication via the endoplasmic reticulum stress pathway. Veterinary Microbiology, 279, 109666.

Ge, Q. Y., Chen, J., Li, G. X., Tan, X. L., Song, J., Ning, D., ... & Zhang, B. X. (2021). GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma. Clinical and Translational Medicine, 11(11), e635.

Besprozvannaya, M., Dickson, E., Li, H., Ginburg, K. S., Bers, D. M., Auwerx, J., & Nunnari, J. (2018). GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Elife, 7, e31019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-GRAMD4 Recombinant Antibody (CBLG1-3205) (CAT#: CBMAB-G4769-LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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