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Mouse Anti-GRIK1 Recombinant Antibody (CBLG1-1746) (CBMAB-G4929-LY)

This product is antibody recognizes GRIK1 . The antibody CBLG1-1746 immunoassay techniques such as: ELISA, ICC, IHC, RIA.
See all GRIK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1746
Antibody Isotype
IgM
Application
ELISA, ICC, IHC, RIA

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutamate receptor, ionotropic, kainate 1
Introduction
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2897
UniProt ID
P39086
Alternative Names
Glutamate Ionotropic Receptor Kainate Type Subunit 1; Excitatory Amino Acid Receptor 3; Glutamate Receptor 5; GluR-5; GLUR5; GluK1;
Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Biological Process
Central nervous system development Source: ProtInc
Chemical synaptic transmission Source: ProtInc
Glutamate receptor signaling pathway Source: ProtInc
Modulation of chemical synaptic transmission Source: GO_Central
Nervous system development Source: ProtInc
Regulation of synaptic transmission, glutamatergic Source: UniProtKB
Synaptic transmission, glutamatergic Source: GO_Central
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 31-576
Helical: 577-597
Cytoplasmic: 598-653
Helical: 654-674
Extracellular: 675-834
Helical: 835-855
Cytoplasmic: 856-918
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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