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Mouse Anti-GRIN3A Recombinant Antibody (CBWJN-0619) (CBMAB-N0867-WJ)

This product is a Mouse antibody that recognizes GRIN3A. The antibody CBWJN-0619 can be used for immunoassay techniques such as: IP, WB.
See all GRIN3A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-0619
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
1.4 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
glutamate ionotropic receptor NMDA type subunit 3A
Introduction
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.
Entrez Gene ID
Human116443
Mouse242443
Rat191573
UniProt ID
HumanQ8TCU5
MouseQ69Z52
RatQ9R1M7
Alternative Names
GluN3A, NMDAR-L, NR3A
Function
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism.
Biological Process
Calcium ion transport Source: UniProtKB
Dendrite development Source: Ensembl
Ionotropic glutamate receptor signaling pathway Source: GO_Central
Negative regulation of dendritic spine development Source: UniProtKB
Prepulse inhibition Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
Response to ethanol Source: UniProtKB
Cellular Location
Cell membrane; Postsynaptic cell membrane; Postsynaptic density. Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity).
Topology
Extracellular: 24-674
Helical: 675-695
Cytoplasmic: 696-748
Helical: 749-769
Extracellular: 770-930
Helical: 931-951
Cytoplasmic: 952-1115
PTM
N-glycosylated.

Ping, A., Yang, M., Xu, S., Li, Q., Feng, Y., Gao, K., ... & Duan, K. (2023). Correlations between GRIN2B and GRIN3A gene polymorphisms and postpartum depressive symptoms in Chinese parturients undergoing cesarean section: A prospective cohort study. Journal of Psychosomatic Research, 168, 111210.

Obolenskaya, M., Dotsenko, V., Martsenyuk, O., Ralchenko, S., Krupko, O., Pastukhov, A., ... & Borisova, T. (2021). A new insight into mechanisms of interferon alpha neurotoxicity: Expression of GRIN3A subunit of NMDA receptors and NMDA-evoked exocytosis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 110, 110317.

Murillo, A., Navarro, A. I., Puelles, E., Zhang, Y., Petros, T. J., & Pérez-Otaño, I. (2021). Temporal dynamics and neuronal specificity of Grin3a expression in the mouse forebrain. Cerebral Cortex, 31(4), 1914-1926.

Zgheib, N. K., El-Khoury, H., Maamari, D., Basbous, M., Saab, R., & Muwakkit, S. A. (2021). A GRIN3A polymorphism may be associated with glucocorticoid-induced symptomatic osteonecrosis in children with acute lymphoblastic leukemia. Personalized Medicine, 18(05), 431-439.

Chen, J., Liu, Q., Fan, R., Han, H., Yang, Z., Cui, W., ... & Li, M. D. (2020). Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies. Addiction Biology, 25(1), e12718.

Wang, R. Y., Chen, H. J., Huang, C. L., Wang, J. Y., Lee, T. E., Lee, H. Y., & Hung, C. C. (2018). Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population. PloS one, 13(7), e0201408.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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