Mouse Anti-GRM1 Recombinant Antibody (1F7) (CBMAB-G5027-LY)

Name: Mouse Anti-GRM1 Recombinant Antibody (1F7)
SKU: CBMAB-G5027-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1F7

Application

ELISA, WB

Immunogen

GST fusion protein

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glutamate metabotropic receptor 1

Introduction

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Entrez Gene ID

2911

UniProt ID

Q13255

Alternative Names

Glutamate Metabotropic Receptor 1; Protein Phosphatase 1; Regulatory Subunit 85; Glutamate Receptor; Metabotropic 1; GPRC1A; MGLUR1; Metabotropic Glutamate Receptor 1;

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890).

May function in the light response in the retina (By similarity).

Biological Process

Activation of MAPK activity Source: Ensembl
Activation of MAPKK activity Source: Ensembl
Cellular response to electrical stimulus Source: Ensembl
Chemical synaptic transmission Source: ProtInc
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
L-glutamate import across plasma membrane Source: Ensembl
Locomotory behavior Source: Ensembl
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: UniProtKB
Regulation of sensory perception of pain Source: Ensembl
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Sensory perception of pain Source: Ensembl

Cellular Location

Cell membrane

Involvement in disease

Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.
Spinocerebellar ataxia 44 (SCA44):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA44 is a slowly progressive, autosomal dominant form.

Topology

Extracellular: 19-592
Helical: 593-615
Cytoplasmic: 616-629
Helical: 630-650
Extracellular: 651-658
Helical: 659-680
Cytoplasmic: 681-703
Helical: 704-727
Extracellular: 728-750
Helical: 751-772
Cytoplasmic: 773-785
Helical: 786-807
Extracellular: 808-815
Helical: 816-840
Cytoplasmic: 841-1194

Sun, S., Kong, Q., Cai, Z., Wang, M., Zhao, H., & Zhao, C. (2021). circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS. International Journal of Molecular Medicine, 48(5), 1-12.

Shah, R., Singh, S. J., Eddy, K., Filipp, F. V., & Chen, S. (2019). Concurrent targeting of glutaminolysis and metabotropic glutamate receptor 1 (GRM1) reduces glutamate bioavailability in GRM1+ melanoma. Cancer research, 79(8), 1799-1809.

Shah, R., Singh, S., Eddy, K., Filipp, F., & Chen, S. (2019). Concurrent inhibition of glutaminase (GLS) and metabotropic receptor 1 (GRM1) reduced glutamate bioavailability and led to a decrease in GRM1-expressing melanoma cell proliferation in vitro and tumor progression in vivo. Cancer Research, 79(13_Supplement), 1839-1839.

Isola, A. L., Eddy, K., Zembrzuski, K., Goydos, J. S., & Chen, S. (2018). Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness. Oncotarget, 9(1), 1187.

Dalley, C. B., Wroblewska, B., Wolfe, B. B., & Wroblewski, J. T. (2018). The role of metabotropic glutamate receptor 1 dependent signaling in glioma viability. Journal of Pharmacology and Experimental Therapeutics, 367(1), 59-70.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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