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Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767)


See all GRM2 antibodies
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Tested Data
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in ELISA
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in ELISA
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in WB
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in WB
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in WB
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in WB
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in FC
Mouse Anti-GRM2 Recombinant Antibody (CBT3901) (V2LY-0625-LY767) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3901
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human GRM2 (AA: extra 414-558) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
2912
UniProt ID
Q14416
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Biological Process
Behavioral response to nicotine Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Gene expression Source: Ensembl
Glutamate homeostasis Source: Ensembl
Glutamate secretion Source: Ensembl
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of adenylate cyclase activity Source: ProtInc
Regulation of dopamine secretion Source: Ensembl
Regulation of glutamate secretion Source: Ensembl
Regulation of protein kinase B signaling Source: ARUK-UCL
Regulation of response to drug Source: Ensembl
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Response to cocaine Source: Ensembl
Cellular Location
Cell membrane; Synapse; Dendrite
Topology
Extracellular: 19-567
Helical: 568-590
Cytoplasmic: 591-604
Helical: 605-625
Extracellular: 626-636
Helical: 637-655
Cytoplasmic: 656-679
Helical: 680-700
Extracellular: 701-725
Helical: 726-747
Cytoplasmic: 748-760
Helical: 761-783
Extracellular: 784-793
Helical: 794-819
Cytoplasmic: 820-872
More Infomation

Ruiz-García, R., Martínez-Hernández, E., Joubert, B., Petit-Pedrol, M., Pajarón-Boix, E., Fernández, V., ... & Graus, F. (2020). Paraneoplastic cerebellar ataxia and antibodies to metabotropic glutamate receptor 2. Neurology-Neuroimmunology Neuroinflammation, 7(2).

Østerbøg, T. B., On, D. M., Oliveras, I., Río-Álamos, C., Sanchez-Gonzalez, A., Tapias-Espinosa, C., ... & Aznar, S. (2020). Metabotropic glutamate receptor 2 and dopamine receptor 2 gene expression predict sensorimotor gating response in the genetically heterogeneous NIH-HS rat strain. Molecular Neurobiology, 57(3), 1516-1528.

Kurth, M., Lolicato, F., Sandoval-Perez, A., Amaya-Espinosa, H., Teslenko, A., Sinning, I., ... & Aponte-Santamaría, C. (2020). Cholesterol Localization around the Metabotropic Glutamate Receptor 2. The Journal of Physical Chemistry B, 124(41), 9061-9078.

Cross, A. J., Anthenelli, R., & Li, X. (2018). Metabotropic glutamate receptors 2 and 3 as targets for treating nicotine addiction. Biological psychiatry, 83(11), 947-954.

Sheahan, T. D., Valtcheva, M. V., McIlvried, L. A., Pullen, M. Y., Baranger, D. A., & Gereau, R. W. (2018). Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human, sensory neurons. Eneuro, 5(2).

Szabó, G., Turos, G. I., Kolok, S., Vastag, M., Sánta, Z., Dekany, M., ... & Keserű, G. M. (2018). Fragment based optimization of metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulators in the absence of structural information. Journal of Medicinal Chemistry, 62(1), 234-246.

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For research use only. Not intended for any clinical use.

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