Mouse Anti-GSTM5 Recombinant Antibody (1B3) (CBMAB-G5521-LY)

Name: Mouse Anti-GSTM5 Recombinant Antibody (1B3)
SKU: CBMAB-G5521-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1B3

Antibody Isotype

IgG2a, κ

Application

ELISA

Basic Information

Immunogen

GSTM5 (NP_000842, 145 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2-1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

glutathione S-transferase mu 5

Introduction

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2949

UniProt ID

P46439

Alternative Names

Glutathione S-Transferase Mu 5; Glutathione S-Transferase M5; GST Class-Mu 5; EC 2.5.1.18; GSTM5-5; S-(Hydroxyalkyl)Glutathione Lyase M5;

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Biological Process

Glutathione metabolic process Source: UniProtKB

Cellular Location

Cytoplasm

More Infomation

References

Shen, C. H., Li, P. Y., Wang, S. C., Wu, S. R., Hsieh, C. Y., Dai, Y. C., & Liu, Y. W. (2023). Epigenetic regulation of human WIF1 and DNA methylation situation of WIF1 and GSTM5 in urothelial carcinoma. Heliyon, 9(5).

Hao, X., Zhang, J., Chen, G., Cao, W., Chen, H., & Chen, S. (2022). Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis. BMC cancer, 22(1), 1-13.

Butrym, A., Łacina, P., Bogunia-Kubik, K., & Mazur, G. (2021). ABCC3 and GSTM5 gene polymorphisms affect overall survival in Polish acute myeloid leukaemia patients. Current Problems in Cancer, 45(5), 100729.

Uno, Y., Murayama, N., Tamura, K., & Yamazaki, H. (2019). Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques. Xenobiotica, 49(8), 995-1000.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-GSTM5 (AA 145-219) Recombinant Antibody (CBFYH-0520)

Mouse Anti-GSTM5 Recombinant Antibody (CBLG1-2039)

Mouse Anti-GSTM5 Recombinant Antibody (CBFYH-0521)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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