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Mouse Anti-GSTO2 Recombinant Antibody (CBFYH-0522) (CBMAB-H1398-FY)

This product is mouse antibody that recognizes GSTO2. The antibody CBFYH-0522 can be used for immunoassay techniques such as: WB.
See all GSTO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0522
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human GSTO2 produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutathione S-Transferase Omega 2
Introduction
The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
119391
UniProt ID
Q9H4Y5
Alternative Names
Glutathione S-Transferase Omega 2; Glutathione-Dependent Dehydroascorbate Reductase; Glutathione S-Transferase Omega 2-2; Monomethylarsonic Acid Reductase; MMA(V) Reductase; EC 2.5.1.18; GSTO 2-2; GSTO-2
Function
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
Biological Process
Cellular response to arsenic-containing substance Source: UniProtKB
Glutathione metabolic process Source: GO_Central
L-ascorbic acid metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Cytoplasm

Petrovic, M., Simic, T., Djukic, T., Radic, T., Savic-Radojevic, A., Zekovic, M., ... & Coric, V. (2023). The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study. Life, 13(6), 1269.

Pavlovic, D., Ristic, S., Djukanovic, L., Matic, M., Kovacevic, M., Pljesa-Ercegovac, M., ... & Djukic, T. (2023). The GSTO2 (rs156697) Polymorphism Modifies Diabetic Nephropathy Risk. Medicina, 59(1), 164.

Peng, X., Zhu, J., Liu, S., Liu, Z., Luo, C., Wu, X., ... & Zhu, Z. (2023). The Upregulation of GSTO2 is Associated with Colon Cancer Progression and a Poor Prognosis. Journal of Oncology, 2023.

Djukic, T., Stevanovic, G., Coric, V., Bukumiric, Z., Pljesa-Ercegovac, M., Matic, M., ... & Simic, T. (2022). GSTO1, GSTO2 and ACE2 polymorphisms modify susceptibility to developing COVID-19. Journal of Personalized Medicine, 12(3), 458.

Sobot, V., Stamenkovic, M., Simic, T., Jerotic, D., Djokic, M., Jaksic, V., ... & Djukic, T. (2022). Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. Experimental Eye Research, 214, 108863.

Wang, X., Zhao, C., Zhang, G., Zhang, K., Li, Z., Shang, Y., ... & Meng, Q. (2022). Molecular characterization of a novel GSTO2 of Fasciola hepatica and its roles in modulating murine macrophages. Parasite, 29.

Sumiya, R., Terayama, M., Hagiwara, T., Nakata, K., Sekihara, K., Nagasaka, S., ... & Kawamura, Y. I. (2022). Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma. Cancer Science, 113(1), 195-204.

Baba, S. M., Pandith, A. A., Shah, Z. A., Geelani, S. A., Bhat, J. R., Gul, A., ... & Mansoor, S. (2021). GSTT1 null and rs156697 Polymorphism in GSTO2 Influence the Risk and Therapeutic Outcome of B-Acute Lymphoblastic Leukemia Patients. Frontiers in Oncology, 11, 714421.

Hamilton, L. E., Zigo, M., Mao, J., Xu, W., Sutovsky, P., O’Flaherty, C., & Oko, R. (2019). GSTO2 isoforms participate in the oxidative regulation of the plasmalemma in eutherian spermatozoa during capacitation. Antioxidants, 8(12), 601.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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