Rabbit Anti-GTF2I Recombinant Antibody (EG1465) (CBMAB-EN1751-LY)

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Basic Information

Host Animal
Rabbit
Clone
EG1465
Application
WB, IHC-P
Immunogen
Synthetic peptide within n-terminal human tfii i.
Specificity
Human, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, BSA, glycerol
Preservative
Sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
general transcription factor IIi
Introduction
This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Entrez Gene ID
Human2969
Rat353256
UniProt ID
HumanP78347
RatQ5U2Y1
Alternative Names
WBS; DIWS; SPIN; IB291; BAP135; BTKAP1; TFII-I; WBSCR6; GTFII-I

Pan, Y., Iejima, D., Nakayama, M., Suga, A., Noda, T., Kaur, I., ... & Iwata, T. (2021). Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro. Journal of Biological Chemistry, 296.

Lee, J., Rho, J. H., Roehrl, M. H., & Wang, J. Y. (2021). Dermatan sulfate is a potential regulator of IgH via interactions with pre-BCR, GTF2I, and BiP ER complex in pre-B lymphoblasts. Frontiers in immunology, 12, 680212.

Liu, C., Yan, S., Chen, H., Wu, Z., Li, L., Cheng, L., ... & Li, Y. (2021). Association of GTF2I, NFKB1, and TYK2 regional polymorphisms with systemic sclerosis in a Chinese Han population. Frontiers in Immunology, 12, 640083.

Shimoyama, S., Nakagawa, I., Jiang, J. J., Matsumoto, I., Chiorini, J. A., Hasegawa, Y., ... & Murakami, M. (2021). Sjögren’s syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development. International immunology, 33(8), 423-434.

Cavallo, F., Troglio, F., Fagà, G., Fancelli, D., Shyti, R., Trattaro, S., ... & Testa, G. (2020). High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11. 23 microduplication autism spectrum disorder patient-derived cortical neurons. Molecular autism, 11(1), 1-18.

Kim, I. K., Rao, G., Zhao, X., Fan, R., Avantaggiati, M. L., Wang, Y., ... & Giaccone, G. (2020). Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells. Cell Death & Differentiation, 27(7), 2263-2279.

Higuchi, R., Goto, T., Hirotsu, Y., Yokoyama, Y., Nakagomi, T., Otake, S., ... & Omata, M. (2020). Primary driver mutations in GTF2I specific to the development of thymomas. Cancers, 12(8), 2032.

Barak, B., Zhang, Z., Liu, Y., Nir, A., Trangle, S. S., Ennis, M., ... & Feng, G. (2019). Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug. Nature neuroscience, 22(5), 700-708.

Kopp, N., McCullough, K., Maloney, S. E., & Dougherty, J. D. (2019). Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models. Human molecular genetics, 28(20), 3443-3465.

Chailangkarn, T., Noree, C., & Muotri, A. R. (2018). The contribution of GTF2I haploinsufficiency to Williams syndrome. Molecular and cellular probes, 40, 45-51.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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