Rabbit Anti-MTG2 Recombinant Antibody (EG1469) (CBMAB-EN1755-LY)

The product is antibody recognizes GTPBP5. The antibody EG1469 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:1000.
See all MTG2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1469

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 ELISA: 1:1000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GTPBP5.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

mitochondrial ribosome associated GTPase 2

Introduction

Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction.

Entrez Gene ID

Human	26164
Mouse	52856
Rat	296462

UniProt ID

Human	Q9H4K7
Mouse	A2AFK4
Rat	Q5XIH5

Alternative Names

ObgH1; GTPBP5; dJ1005F21.2

Function

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process.

Biological Process

Regulation of mitochondrial translation Source: UniProtKB
Regulation of respiratory system process Source: UniProtKB
Ribosome biogenesis Source: UniProtKB-KW

Cellular Location

Mitochondrion
Mitochondrion inner membrane

References

Maiti, P., Antonicka, H., Gingras, A. C., Shoubridge, E. A., & Barrientos, A. (2020). Human GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation. Nucleic acids research, 48(14), 7924-7943.

Xu, D., Zhao, Y., Weng, X., Lu, Y., Li, W., Tang, K., ... & Xu, Y. (2019). Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy. Journal of Molecular and Cellular Cardiology, 128, 105-116.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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