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Mouse Anti-H1FX Recombinant Antibody (CBFYH-0570) (CBMAB-H1456-FY)

This product is mouse antibody that recognizes H1FX. The antibody CBFYH-0570 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all H1FX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0570
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
H1 Histone Family Member X
Introduction
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family.
Entrez Gene ID
8971
UniProt ID
Q92522
Alternative Names
H1 Histone Family Member X; H1 Histone Family, Member X; Histone H1x; H1.10; H1X
Function
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
Biological Process
Chromosome condensation Source: GO_Central
Negative regulation of DNA recombination Source: GO_Central
Nucleosome assembly Source: InterPro
Nucleosome positioning Source: GO_Central
Cellular Location
Nucleus; Chromosome
PTM
Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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