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Mouse Anti-H2AC6 Recombinant Antibody (4F10) (CBMAB-A3917-LY)

The product is antibody recognizes HIST1H2AC. The antibody 4F10 immunoassay techniques such as: sELISA, ELISA.
See all H2AC6 antibodies
Published Data
Fig.1 Analysis of the interaction of H2ac with TRF2 and POT1 by co-immunoprecipitation.
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Fig.2 The amino-terminal basic domain of TRF2 is required for H2ac recruitment to telomeres.
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Fig.3 H2ac depletion induces telomere-repeat loss and telomere dysfunction.
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Fig.4 H2ac knockdown triggers an ATM-dependent DNA damage signal at telomeres.
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Fig.5 XPF is essential for the H2ac depletion-mediated DNA damage response and genome abnormalities.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F10
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
HIST1H2AC (NP_003503, 25 a.a. ~ 96 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq]
Entrez Gene ID
8334
UniProt ID
Q93077
Alternative Names
H2A/l; H2AFL; MGC99519; dJ221C16.4
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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