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Mouse Anti-HAL (AA 558-658) Recombinant Antibody (CBFYH-0671) (CBMAB-H1557-FY)

This product is mouse antibody that recognizes HAL. The antibody CBFYH-0671 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all HAL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0671
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 558-658

Target

Full Name
Histidine Ammonia-Lyase
Introduction
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
3034
UniProt ID
P42357
Alternative Names
Histidine Ammonia-Lyase; EC 4.3.1.3; Histidase; HIS; EC 4.3.1; HSTD
Biological Process
Histidine catabolic process Source: GO_Central
Histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
Histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Cellular Location
Cytosol
Involvement in disease
Histidinemia (HISTID):
Autosomal recessive disease characterized by increased histidine and histamine as well as decreased urocanic acid in body fluids.
PTM
Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.

Rivera-Paredez, B., Hidalgo-Bravo, A., León-Reyes, G., Barajas-Olmos, F., Martínez-Hernández, A., Orozco, L., ... & Velázquez-Cruz, R. (2023). The role of single nucleotide variant rs3819817 of the Histidine Ammonia-Lyase gene and 25-Hydroxyvitamin D on bone mineral density, adiposity markers, and skin pigmentation, in Mexican population. Journal of Endocrinological Investigation, 1-11.

Muramatsu, H., Harada, T., Sugihara, D., Hashimoto, K., Kato, S. I., Nagata, S., & Shimamura, T. (2022). Enzymatic determination of carnosine in meat and fish using β-ala-xaa dipeptidase and histidine ammonia-lyase derived from Pseudomonas putida NBRC100650. Analytical Sciences, 38(2), 331-338.

Ade, C., Marcelino, T. F., Dulchavsky, M., Wu, K., Bardwell, J. C., & Städler, B. (2022). Microreactor equipped with naturally acid-resistant histidine ammonia lyase from an extremophile. Materials advances, 3(8), 3649-3662.

Mantilla, B. S., Azevedo, C., Denny, P. W., Saiardi, A., & Docampo, R. (2021). The histidine ammonia lyase of Trypanosoma cruzi is involved in acidocalcisome alkalinization and is essential for survival under starvation conditions. Mbio, 12(6), e01981-21.

Zare, D., Muhammad, K., & Ghazali, H. M. (2021). The manner of urocanic acid accumulation in fish by tracking histidine ammonia lyase activity during storage of vacuum‐packed, eviscerated, and whole fish. Journal of Food Processing and Preservation, 45(3), e15288.

Zhang, F., Ren, J., & Zhan, J. (2021). Identification and characterization of an efficient phenylalanine ammonia-lyase from Photorhabdus luminescens. Applied Biochemistry and Biotechnology, 193, 1099-1115.

Miranda, R. R., Silva, M., Barisón, M. J., Silber, A. M., & Iulek, J. (2020). Crystal structure of histidine ammonia-lyase from Trypanosoma cruzi. Biochimie, 175, 181-188.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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