Mouse Anti-HAS1 Recombinant Antibody (CBT4166) (V2LY-0625-LY2453)

Name: Mouse Anti-HAS1 Recombinant Antibody (CBT4166)
SKU: V2LY-0625-LY2453
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-HAS1 Recombinant Antibody (CBT4166) (V2LY-0625-LY2453) in WB

Mouse Anti-HAS1 Recombinant Antibody (CBT4166) (V2LY-0625-LY2453) in IF

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4166

Application

ICC

Immunogen

Purified recombinant fragment of human HAS1 expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:200-1:1,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Hyaluronan Synthase 1

Entrez Gene ID

3036

UniProt ID

Q92839

Function

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).

Biological Process

Cell adhesion Source: ProtInc
Cellular response to platelet-derived growth factor stimulus Source: UniProtKB
Extracellular matrix assembly Source: UniProtKB
Extracellular polysaccharide biosynthetic process Source: UniProtKB
Glycosaminoglycan biosynthetic process Source: ProtInc
Hyaluronan biosynthetic process Source: GO_Central
Negative regulation of fibroblast migration Source: UniProtKB

Cellular Location

Membrane

Topology

Cytoplasmic: 1-25
Helical: 26-46
Extracellular: 47-52
Helical: 53-73
Cytoplasmic: 74-399
Helical: 400-420
Extracellular: 421-430
Helical: 431-451
Cytoplasmic: 452-457
Helical: 458-478
Extracellular: 479-497
Helical: 498-518
Cytoplasmic: 519-540
Helical: 541-561
Extracellular: 562-578

Passi, A., Vigetti, D., Buraschi, S., & Iozzo, R. V. (2019). Dissecting the role of hyaluronan synthases in the tumor microenvironment. The FEBS journal, 286(15), 2937-2949.

Oikari, S., Kettunen, T., Tiainen, S., Häyrinen, J., Masarwah, A., Sudah, M., ... & Auvinen, P. (2018). UDP-sugar accumulation drives hyaluronan synthesis in breast cancer. Matrix Biology, 67, 63-74.

Sikes, K. J., Renner, K., Li, J., Grande‐Allen, K. J., Connell, J. P., Cali, V., ... & Wang, V. M. (2018). Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa. Journal of Orthopaedic Research®, 36(10), 2622-2632.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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