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Mouse Anti-HAS1 Recombinant Antibody (IHC591) (CBMAB-MA111-YC)

Provided herein is a Mouse monoclonal antibody against Hyaluronan Synthase 1. The antibody can be used for immunoassay techniques, such as IHC. And it gave a positive signal in Testes.
See all HAS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC591
Application
IHC (1:100 - 1:200)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
Hyaluronan Synthase 1
Introduction
HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.
Entrez Gene ID
3036
UniProt ID
Q92839
Alternative Names
Hyaluronan Synthase 1; Hyaluronic Acid Synthase 1; Hyaluronate Synthase 1; HA Synthase 1; HAS; EC 2.4.1.212; HuHAS1;
Function
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).
Biological Process
Cell adhesion Source: ProtInc
Cellular response to platelet-derived growth factor stimulus Source: UniProtKB
Extracellular matrix assembly Source: UniProtKB
Extracellular polysaccharide biosynthetic process Source: UniProtKB
Glycosaminoglycan biosynthetic process Source: ProtInc
Hyaluronan biosynthetic process Source: GO_Central
Negative regulation of fibroblast migration Source: UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-25
Helical: 26-46
Extracellular: 47-52
Helical: 53-73
Cytoplasmic: 74-399
Helical: 400-420
Extracellular: 421-430
Helical: 431-451
Cytoplasmic: 452-457
Helical: 458-478
Extracellular: 479-497
Helical: 498-518
Cytoplasmic: 519-540
Helical: 541-561
Extracellular: 562-578
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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