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Mouse Anti-HEXIM2 Recombinant Antibody (CBFYH-0984) (CBMAB-H1925-FY)

This product is mouse antibody that recognizes HEXIM2. The antibody CBFYH-0984 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all HEXIM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0984
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hexamethylene Bisacetamide Inducible 2
Introduction
This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
124790
UniProt ID
Q96MH2
Alternative Names
Hexamethylene Bisacetamide Inducible 2; Hexamethylene Bis-Acetamide-Inducible Protein 2; Hexamethylene Bis-Acetamide Inducible 2; Hexamethylene-Bis-Acetamide-Inducible Transcript 2; Protein HEXIM2; MAQ1 Paralog; L3
Function
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662).

Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662).
Biological Process
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC-UCL
Negative regulation of transcription, DNA-templated Source: HGNC-UCL
Negative regulation of transcription by RNA polymerase II Source: HGNC-UCL
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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