Mouse Anti-HEY2 Antibody (1H10) (CBMAB-0462-YC)

hes related family bHLH transcription factor with YRPW motif 2

HEY2 (hes-related family bHLH transcription factor with YRPW motif 2) is a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. Expression of HEY2 is induced by the Notch signal transduction pathway and forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription.

bHLHb32; HERP1; HESR2

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

Anterior/posterior axis specification Source: Ensembl
Anterior/posterior pattern specification Source: GO_Central
Aortic valve morphogenesis Source: BHF-UCL
Arterial endothelial cell differentiation Source: BHF-UCL
Ascending aorta morphogenesis Source: BHF-UCL
Atrial septum morphogenesis Source: BHF-UCL
Cardiac conduction system development Source: BHF-UCL
Cardiac epithelial to mesenchymal transition Source: BHF-UCL
Cardiac left ventricle morphogenesis Source: BHF-UCL
Cardiac muscle hypertrophy in response to stress Source: Ensembl
Cardiac right ventricle morphogenesis Source: BHF-UCL
Cardiac septum morphogenesis Source: BHF-UCL
Cardiac vascular smooth muscle cell development Source: Ensembl
Cardiac ventricle morphogenesis Source: UniProtKB
Cell fate commitment Source: Ensembl
Circulatory system development Source: GO_Central
Cochlea development Source: Ensembl
Coronary vasculature morphogenesis Source: Ensembl
Dorsal aorta morphogenesis Source: BHF-UCL
Endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
Heart trabecula formation Source: Ensembl
Labyrinthine layer blood vessel development Source: BHF-UCL
Mesenchymal cell development Source: BHF-UCL
Muscular septum morphogenesis Source: BHF-UCL
Negative regulation of biomineral tissue development Source: BHF-UCL
Negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
Negative regulation of cardiac vascular smooth muscle cell differentiation Source: BHF-UCL
Negative regulation of gene expression Source: UniProtKB
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
Negative regulation of transcription initiation from RNA polymerase II promoter Source: BHF-UCL
Negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
Notch signaling involved in heart development Source: BHF-UCL
Notch signaling pathway Source: UniProtKB
Outflow tract morphogenesis Source: BHF-UCL
Positive regulation of cardiac muscle cell proliferation Source: Ensembl
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of heart rate Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein-DNA complex assembly Source: Ensembl
Pulmonary artery morphogenesis Source: BHF-UCL
Pulmonary valve morphogenesis Source: BHF-UCL
Regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of vasculogenesis Source: BHF-UCL
Smooth muscle cell differentiation Source: BHF-UCL
Tricuspid valve formation Source: Ensembl
Tricuspid valve morphogenesis Source: BHF-UCL
Umbilical cord morphogenesis Source: BHF-UCL
Vascular associated smooth muscle cell development Source: UniProtKB
Vasculogenesis Source: BHF-UCL
Ventricular cardiac muscle cell development Source: UniProtKB
Ventricular septum morphogenesis Source: BHF-UCL
Ventricular trabecula myocardium morphogenesis Source: Ensembl

Nucleus