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Mouse Anti-HFE2 Recombinant Antibody (1C12) (CBMAB-A3875-LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
1C12
Application
WB, ELISA
Immunogen
HFE2 (NP_973733, 93 a.a. ~ 173 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
hemochromatosis type 2 (juvenile)
Introduction
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq]
Entrez Gene ID
148738
UniProt ID
Q6ZVN8
Alternative Names
HFE2A; HJV; JH; MGC23953; RGMC
Biological Process
BMP signaling pathway Source: Ensembl
Cellular iron ion homeostasis Source: Ensembl
Negative regulation of BMP signaling pathway Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Cellular Location
Cell membrane; Membrane
Topology
Helical: 405-425

Mutlu, T., Ozoran, E., Trabulus, D. C., Talu, C. K., Erhan, D., Mete, M., & Guven, M. (2023). Expression of genes related to iron homeostasis in breast cancer. Molecular Biology Reports, 1-7.

Bharadwaj, N., Peyam, S., Bhatia, P., Bhatia, A., Das, R., Singh, M., ... & Jain, R. (2022). Impact of HFE-2 and HAMP Gene Variations on Iron Overload in Pediatric Patients with Non-Transfusion Dependent Thalassemia: A Pilot Study. Indian Journal of Hematology and Blood Transfusion, 38(1), 158-163.

Seyoum, Y., Baye, K., & Humblot, C. (2021). Iron homeostasis in host and gut bacteria–a complex interrelationship. Gut Microbes, 13(1), 1874855.

Julián-Serrano, S., Yuan, F., Wheeler, W., Benyamin, B., Machiela, M. J., Arslan, A. A., ... & Stolzenberg-Solomon, R. Z. (2021). Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies. The American journal of clinical nutrition, 114(4), 1408-1417.

Sukhbaatar, N., & Weichhart, T. (2018). Iron regulation: macrophages in control. Pharmaceuticals, 11(4), 137.

Kawabata, H. (2018). The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis. International journal of hematology, 107(1), 31-43.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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