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Mouse Anti-HFM1 Recombinant Antibody (CBFYM-1125) (CBMAB-M1282-FY)

This product is mouse antibody that recognizes HFM1. The antibody CBFYM-1125 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all HFM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1125
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HFM1, ATP Dependent DNA Helicase Homolog
Introduction
The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9.
Entrez Gene ID
164045
UniProt ID
A2PYH4
Alternative Names
HFM1, ATP Dependent DNA Helicase Homolog; SEC63 Domain-Containing Protein 1; HFM1, ATP-Dependent DNA Helicase Homolog (S. Cerevisiae); Probable ATP-Dependent DNA Helicase HFM1; Helicase-Like Protein HFM1; SEC63 Domain Containing 1; EC 3.6.4.12; Helicase
Function
Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.
Biological Process
Resolution of meiotic recombination intermediates Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Premature ovarian failure 9 (POF9):
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Ying, Y., Meng, Y., Bian, L., Zhang, M., Zhou, P., Zhang, S., ... & Li, D. (2023). The prognostic value and biological functions of HFM1 in breast cancer. Epigenomics, 15(3), 147-166.

Yu, L., Li, M., Zhang, H., He, Q., Wan, F., Zhang, C., & Wang, F. (2022). Novel pathogenic splicing variants in helicase for meiosis 1 (HFM1) are associated with diminished ovarian reserve and poor pregnancy outcomes. Journal of Assisted Reproduction and Genetics, 39(9), 2135-2141.

Xie, X., Murtaza, G., Li, Y., Zhou, J., Ye, J., Khan, R., ... & Shi, Q. (2022). Biallelic HFM1 variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degrees. Human Reproduction, 37(7), 1664-1677.

Saebnia, N., Ebrahimzadeh-Vesal, R., Haddad-Mashhadrizeh, A., Gholampour-Faroji, N., Schinzel, A., Neshati, Z., & Azimi-Nezhad, M. (2022). Identification of a new splice-acceptor mutation in HFM1 and functional analysis through molecular docking in nonobstructive azoospermia. Journal of assisted reproduction and genetics, 39(5), 1195-1203.

Tang, D., Lv, M., Gao, Y., Cheng, H., Li, K., Xu, C., ... & Cao, Y. (2021). Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia. Reproductive Biology and Endocrinology, 19(1), 1-12.

Zhe, J., Chen, S., Chen, X., Liu, Y., Li, Y., Zhou, X., & Zhang, J. (2019). A novel heterozygous splice-altering mutation in HFM1 may be a cause of premature ovarian insufficiency. Journal of ovarian research, 12, 1-9.

Wang, H., Zhong, C., Yang, R., Yin, Y., Tan, R., Gao, L., ... & Wu, J. (2020). Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis. Cell Death & Disease, 11(6), 490.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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