Mouse Anti-HINFP Antibody (1A1) (CBMAB-0473-YC)

Name: Mouse Anti-HINFP Antibody (1A1)
SKU: CBMAB-0473-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A1

Application

IP, MA

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

HINFP

Introduction

HINFP (histone h4 transcription factor) is a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex. HINFP plays a role in DNA methylation and transcription repression.

Entrez Gene ID

25988

UniProt ID

Q9BQA5

Alternative Names

HiNF-P; MIZF; ZNF743

Function

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Biological Process

Anatomical structure development Source: GO_Central
DNA damage checkpoint signaling Source: UniProtKB
DNA repair Source: UniProtKB
Establishment of protein localization Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
In utero embryonic development Source: UniProtKB
Myoblast differentiation Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
Regulation of gene expression Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
Transcription, DNA-templated Source: Ensembl

Cellular Location

Nucleus. Associated with discrete nuclear foci.

PTM

Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.

Zheng, X., Liu, Z., Zhong, J., Zhou, L., Chen, J., Zheng, L., ... & Kang, T. (2022). Downregulation of HINFP induces senescence-associated secretory phenotype to promote metastasis in a non-cell-autonomous manner in bladder cancer. Oncogene, 41(28), 3587-3598.

Nirala, N. K., Li, Q., Ghule, P. N., Chen, H. J., Li, R., Zhu, L. J., ... & Ip, Y. T. (2021). Hinfp is a guardian of the somatic genome by repressing transposable elements. Proceedings of the National Academy of Sciences, 118(41), e2100839118.

Gupta, R., & Kumar, P. (2021). CREB1K292 and HINFPK330 as Putative Common Therapeutic Targets in Alzheimer’s and Parkinson’s Disease. ACS omega, 6(51), 35780-35798.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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