HINFP

This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.

Full Name

HINFP

Function

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Biological Process

Anatomical structure development Source: GO_Central
DNA damage checkpoint signaling Source: UniProtKB
DNA repair Source: UniProtKB
Establishment of protein localization Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
In utero embryonic development Source: UniProtKB
Myoblast differentiation Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
Regulation of gene expression Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
Transcription, DNA-templated Source: Ensembl

Cellular Location

Nucleus. Associated with discrete nuclear foci.

PTM

Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.