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Mouse Anti-HJURP Monoclonal Antibody (CBFYH-3090) (CBMAB-H2184-FY)

This product is mouse antibody that recognizes HJURP. The antibody CBFYH-3090 can be used for immunoassay techniques such as: WB, IHC-P, IHC-Fr, IF.
See all HJURP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3090
Antibody Isotype
IgG1
Application
WB, IHC-P, IHC-Fr, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Holliday Junction Recognition Protein
Introduction
HJURP (Holliday Junction Recognition Protein) is a Protein Coding gene. Diseases associated with HJURP include Fibrillary Astrocytoma. Among its related pathways are Chromosome Maintenance and DNA Damage. Gene Ontology (GO) annotations related to this gene include identical protein binding and histone binding.
Entrez Gene ID
55355
UniProt ID
Q8NCD3
Alternative Names
Holliday Junction Recognition Protein; Fetal Liver-Expressing Gene 1 Protein; 14-3-3-Associated AKT Substrate; Up-Regulated In Lung Cancer 9; FAKTS; URLC9; Fetal Liver Expressing Gene 1; HFLEG1; FLEG1
Function
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Biological Process
Cell cycle Source: UniProtKB-KW
CENP-A containing chromatin assembly Source: UniProtKB
Chromosome segregation Source: UniProtKB
Regulation of DNA binding Source: UniProtKB
Regulation of protein-containing complex assembly Source: UniProtKB
Cellular Location
Nucleolus; Centromere. Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.

Dou, Z., Qiu, C., Zhang, X., Yao, S., Zhao, C., Wang, Z., ... & Kong, B. (2022). HJURP promotes malignant progression and mediates sensitivity to cisplatin and WEE1-inhibitor in serous ovarian cancer. International Journal of Biological Sciences, 18(3), 1188.

Mao, M., Jia, Y., Chen, Y., Yang, J., Xu, L., Zhang, X., ... & Wang, L. (2022). HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer. Cell Death & Disease, 13(4), 396.

Lai, W., Zhu, W., Xiao, C., Li, X., Wang, Y., Han, Y., ... & Wen, X. (2021). HJURP promotes proliferation in prostate cancer cells through increasing CDKN1A degradation via the GSK3β/JNK signaling pathway. Cell death & disease, 12(6), 583.

Zhang, F., Yuan, D., Song, J., Chen, W., Wang, W., Zhu, G., ... & Zhu, J. (2021). HJURP is a prognostic biomarker for clear cell renal cell carcinoma and is linked to immune infiltration. International Immunopharmacology, 99, 107899.

Li, Y., Yi, Q., Liao, X., Han, C., Zheng, L., Li, H., ... & Huang, W. (2021). Hypomethylation-driven overexpression of HJURP promotes progression of hepatocellular carcinoma and is associated with poor prognosis. Biochemical and Biophysical Research Communications, 566, 67-74.

Chen, T., Zhou, L., Zhou, Y., Zhou, W., Huang, H., Yin, S., ... & Zheng, S. (2019). HJURP promotes epithelial-to-mesenchymal transition via upregulating SPHK1 in hepatocellular carcinoma. International journal of biological sciences, 15(6), 1139.

Pan, D., Walstein, K., Take, A., Bier, D., Kaiser, N., & Musacchio, A. (2019). Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing. Nature Communications, 10(1), 4046.

Zasadzińska, E., Huang, J., Bailey, A. O., Guo, L. Y., Lee, N. S., Srivastava, S., ... & Foltz, D. R. (2018). Inheritance of CENP-A nucleosomes during DNA replication requires HJURP. Developmental cell, 47(3), 348-362.

Chen, T., Huang, H., Zhou, Y., Geng, L., Shen, T., Yin, S., ... & Zheng, S. (2018). HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways. Journal of Experimental & Clinical Cancer Research, 37(1), 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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