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Mouse Anti-HLA-G Recombinant Antibody (A241) (CBMAB-AP9788LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A241
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant protein of human HLA-G
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
3135
UniProt ID
P17693
Alternative Names
MHC-G
Function
A10182
Biological Process
Antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: UniProtKB
Antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
Cellular defense response Source: ProtInc
Immune response-inhibiting cell surface receptor signaling pathway Source: BHF-UCL
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of dendritic cell differentiation Source: BHF-UCL
Negative regulation of G0 to G1 transition Source: UniProtKB
Negative regulation of immune response Source: UniProtKB
Negative regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Negative regulation of protein kinase B signaling Source: UniProtKB
Negative regulation of T cell mediated cytotoxicity Source: UniProtKB
Negative regulation of T cell proliferation Source: BHF-UCL
Peripheral B cell tolerance induction Source: UniProtKB
Positive regulation of cellular senescence Source: UniProtKB
Positive regulation of endothelial cell apoptotic process Source: UniProtKB
Positive regulation of interleukin-12 production Source: BHF-UCL
Positive regulation of macrophage cytokine production Source: UniProtKB
Positive regulation of natural killer cell cytokine production Source: UniProtKB
Positive regulation of regulatory T cell differentiation Source: BHF-UCL
Positive regulation of T cell tolerance induction Source: BHF-UCL
Positive regulation of tolerance induction Source: UniProtKB
Protection from natural killer cell mediated cytotoxicity Source: UniProtKB
Protein homotrimerization Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane; Early endosome membrane; Endoplasmic reticulum membrane
Chain Soluble HLA class I histocompatibility antigen, alpha chain G: Secreted
Isoform 2: Cell membrane
Isoform 3: Cell membrane
Isoform 4: Cell membrane
Isoform 5: Secreted; Early endosome
Isoform 6: Secreted
Isoform 7: Secreted; Filopodium membrane. HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells.
Topology
Extracellular: 25-308
Helical: 309-332
Cytoplasmic: 333-338
PTM
N-glycosylated.
Soluble HLA class I histocompatibility antigen, alpha chain G:
Produced by proteolytic cleavage at the cell surface (shedding) by matrix metalloproteinase MMP2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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