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Mouse Anti-HMBOX1 Monoclonal Antibody (CBFYH-3156) (CBMAB-H2444-FY)

This product is mouse antibody that recognizes HMBOX1. The antibody CBFYH-3156 can be used for immunoassay techniques such as: Dot.
See all HMBOX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3156
Antibody Isotype
IgG1
Application
Dot

Basic Information

Immunogen
HMBOX1 antibody was raised in mouse using recombinant Human Homeobox Containing 1Immunogen type: Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Homeobox Containing 1
Introduction
HMBOX1 (Homeobox Containing 1) is a Protein Coding gene.
Entrez Gene ID
79618
UniProt ID
Q6NT76
Alternative Names
Homeobox Containing 1; Homeobox Telomere-Binding Protein 1; Homeobox-Containing Protein PBHNF; Homeobox-Containing Protein 1; HNF1LA; PBHNF; HOT1
Function
Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356).

Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356).

Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity).

Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958).

Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958).

Might also be involved in the DNA damage response at telomeres (PubMed:23813958).
Biological Process
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of chromatin binding Source: BHF-UCL
Positive regulation of telomerase activity Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: InterPro
Regulation of telomerase activity Source: BHF-UCL
Cellular Location
Cytoplasm; Nucleus; Cajal body; PML body; Telomere. Predominantly detected in cytoplasm (PubMed:16825764, PubMed:19728927). Localizes in a dynamic manner to actively processed telomeres (PubMed:23685356). Localizes to the periphery of Cajal bodies (PubMed:23685356). Associates with PML nuclear bodies in telomerase-negative cells (PubMed:23813958).
Isoform 5: Cytoplasm; Nucleus

Jiang, Y., Mu, H., & Zhao, H. (2023). HMBOX1, a member of the homeobox family: current research progress. Central European Journal of Immunology, 48(1).

Jiang, W., Jiang, Y., Zhang, X., Mu, H., Song, Y., & Zhao, H. (2023). Metabolomic analysis reveals the influence of HMBOX1 on RAW264. 7 cells proliferation based on UPLC-MS/MS. BMC genomics, 24(1), 272.

Zhu, X., Fu, H., Sun, J., Di, Q., & Xu, Q. (2022). N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury. Life Sciences, 309, 121005.

Nie, M., Li, H., Liu, P., & Dang, P. (2022). HMBOX1 attenuates LPS‑induced periodontal ligament stem cell injury by inhibiting CXCL10 expression through the NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 23(3), 1-10.

Chen, S., Li, Y., Zhi, S., Ding, Z., Wang, W., Peng, Y., ... & Li, J. (2020). WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner. Cell death & disease, 11(8), 659.

Ma, H., Su, L., He, X., & Miao, J. (2019). Loss of HMBOX1 promotes LPS-induced apoptosis and inhibits LPS-induced autophagy of vascular endothelial cells in mouse. Apoptosis, 24, 946-957.

Diao, N., Li, Y., Yang, J., Jin, C., Meng, X., Jiao, W., ... & Lu, N. (2019). High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration. Biomedicine & Pharmacotherapy, 115, 108867.

Zhao, H., Han, Q., Lu, N., Xu, D., Tian, Z., & Zhang, J. (2018). HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation. Molecular immunology, 101, 303-311.

Yu, Y. L., Diao, N. N., Li, Y. Z., Meng, X. H., Jiao, W. L., Feng, J. B., ... & Lu, N. (2018). Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis. Biochemical and Biophysical Research Communications, 501(2), 380-386.

Zhou, J., Wang, M., & Deng, D. (2018). c-Fos/microRNA-18a feedback loop modulates the tumor growth via HMBOX1 in human gliomas. Biomedicine & Pharmacotherapy, 107, 1705-1711.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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