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Mouse Anti-HMGN3 (AA 1-77) Recombinant Antibody (CBFYH-1554) (CBMAB-H2531-FY)

This product is mouse antibody that recognizes HMGN3. The antibody CBFYH-1554 can be used for immunoassay techniques such as: ELISA.
See all HMGN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1554
Antibody Isotype
IgM, k
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPAPPKPE PKPRKTSAKK EPGAKISRGA KGKKEEKQEA GKEGTEN
Specificity
Human
Antibody Isotype
IgM, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-77

Target

Full Name
High Mobility Group Nucleosomal Binding Domain 3
Introduction
The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1.
Entrez Gene ID
9324
UniProt ID
Q15651
Alternative Names
High Mobility Group Nucleosomal Binding Domain 3; TR-Interacting Protein 7; TRIP7; High Mobility Group Nucleosome-Binding Domain-Containing Protein 3; Thyroid Hormone Receptor Interacting Protein 7; Thyroid Receptor-Interacting Protein 7
Function
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
Biological Process
Chromatin organization Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: InterPro
Regulation of insulin secretion involved in cellular response to glucose stimulus Source: InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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