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Mouse Anti-JPT1 Recombinant Antibody (2C8) (CBMAB-A3983-LY)

The product is antibody recognizes HN1. The antibody 2C8 immunoassay techniques such as: WB, ELISA.
See all JPT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C8
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HN1 (AAH01420, 1 a.a. ~ 154 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Jupiter microtubule associated homolog 1
Entrez Gene ID
51155
UniProt ID
Q9UK76
Alternative Names
ARM2; HN1A
Function
Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408).
Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422).
Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365).
Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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