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Mouse Anti-HNF4G Recombinant Antibody (B6502A) (CBMAB-H2603-FY)

This product is mouse antibody that recognizes HNF4G. The antibody B6502A can be used for immunoassay techniques such as: WB, IP, ELISA, IHC-P.
See all HNF4G antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human
Clone
B6502A
Antibody Isotype
IgG1
Application
WB, IP, ELISA, IHC-P

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hepatocyte nuclear factor 4, gamma
Introduction
HNF4G (Hepatocyte Nuclear Factor 4 Gamma) is a Protein Coding gene. Diseases associated with HNF4G include Maturity-Onset Diabetes Of The Young. Among its related pathways are Gene Expression and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and steroid hormone receptor activity. An important paralog of this gene is HNF4A.
Entrez Gene ID
Human3174
Rat365744
UniProt ID
HumanQ14541
RatF1M342
Alternative Names
Hepatocyte Nuclear Factor 4 Gamma; Nuclear Receptor Subfamily 2 Group A Member 2; HNF-4-Gamma; NR2A2; Hepatocyte Nuclear Factor 4-Gamma; NR2A3
Function
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
Biological Process
Anatomical structure development Source: GO_Central
Cell differentiation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Liang, J., Zhao, G., Bian, Y., Bi, G., Sui, Q., Zhang, H., ... & Zhan, C. (2023). HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway. PeerJ, 11, e14996.

Zhan, J., Zhang, Q., Tong, X., Liu, X., & Zhao, C. (2023). HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription. Clinical and Translational Oncology, 25(5), 1472-1481.

Che, H., Zheng, Q., Liao, Z., & Zhang, L. (2023). HNF4G accelerates glioma progression by facilitating NRP1 transcription. Oncology Letters, 25(3), 1-12.

He, X. X., Luo, S. S., Qin, H. Q., & Mo, X. W. (2022). MicroRNA-766-3p-mediated downregulation of HNF4G inhibits proliferation in colorectal cancer cells through the PI3K/AKT pathway. Cancer Gene Therapy, 29(6), 803-813.

Ayari, S., Gil-Iturbe, E., Le Gléau, L., Osinski, C., Kapel, N., Soula, H. A., ... & Ribeiro, A. (2022). HNF4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption. Journal of Endocrinology, 252(1), 31-44.

Chen, L., Shi, H., Wang, X., Wang, T., Wang, Y., Wu, Z., ... & Li, Q. (2022). Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer. European Journal of Pharmacology, 916, 174727.

Thymiakou, E., Xenikaki, E., & Kardassis, D. (2022). Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1867(3), 159108.

Wang, C., Zhang, T., Liao, Q., Dai, M., Guo, J., Yang, X., ... & Zhao, Y. (2021). Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation. Protein & cell, 12(2), 128-144.

Ma, Y. S., Shi, B. W., Guo, J. H., Liu, J. B., Yang, X. L., Xin, R., ... & Fu, D. (2021). microRNA-320b suppresses HNF4G and IGF2BP2 expression to inhibit angiogenesis and tumor growth of lung cancer. Carcinogenesis, 42(5), 762-771.

Wang, J., Zhang, J., Xu, L., Zheng, Y., Ling, D., & Yang, Z. (2018). Expression of HNF4G and its potential functions in lung cancer. Oncotarget, 9(26), 18018.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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