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Mouse Anti-HNRNPC Recombinant Antibody (CBFYH-1639) (CBMAB-H2642-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYH-1639
Application
WB, IP, ELISA, IHC-P, IF
Specificity
Mouse, Chicken, Hamster, Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
heterogeneous nuclear ribonucleoprotein C (C1/C2)
Introduction
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.
Entrez Gene ID
Human3183
Mouse15381
Chicken121108713
Hamster100751290
Monkey706423
UniProt ID
HumanP07910
MouseQ9Z204
HamsterA0A1U8D1D9
MonkeyA0A2K5U148
Alternative Names
Heterogeneous Nuclear Ribonucleoprotein C (C1/C2); HnRNP C1/C2; HNRPC; Heterogeneous Nuclear Ribonucleoproteins C1/C2; Nuclear Ribonucleoprotein Particle C1 Protein; Nuclear Ribonucleoprotein Particle C2 Protein
Function
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621).

Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).

Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621).

May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Biological Process
3'-UTR-mediated mRNA stabilization Source: UniProtKB
Chromatin remodeling Source: GO_Central
mRNA splicing, via spliceosome Source: UniProtKB
Negative regulation of telomere maintenance via telomerase Source: BHF-UCL
Osteoblast differentiation Source: UniProtKB
RNA splicing Source: ProtInc
Cellular Location
Nucleus. Component of ribonucleosomes.
PTM
Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
Sumoylated. Sumoylation reduces affinity for mRNA.

Mo, L., Meng, L., Huang, Z., Yi, L., Yang, N., & Li, G. (2022). An analysis of the role of HnRNP C dysregulation in cancers. Biomarker Research, 10(1), 19.

Yang, L., WenTao, T., ZhiYuan, Z., Qi, L., YuXiang, L., Peng, Z., ... & JianMin, X. (2022). Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by MDM2 inhibition in colorectal cancer. Oncogene, 41(23), 3210-3221.

Zhang, X., Chu, H., Chik, K. K. H., Wen, L., Shuai, H., Yang, D., ... & Chan, J. F. W. (2022). hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs. Emerging Microbes & Infections, 11(1), 519-531.

Zhu, W., Wang, J., Liu, X., Xu, Y., Zhai, R., Zhang, J., ... & Liu, L. (2022). lncRNA CYTOR promotes aberrant glycolysis and mitochondrial respiration via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma. Cell Death & Disease, 13(8), 703.

Lv, W., Tan, Y., Xiong, M., Zhao, C., Wang, Y., Wu, M., ... & Zhang, Q. (2021). Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression. Journal of Translational Medicine, 19(1), 527.

Huang, X. T., Li, J. H., Zhu, X. X., Huang, C. S., Gao, Z. X., Xu, Q. C., ... & Yin, X. Y. (2021). HNRNPC impedes m6A-dependent anti-metastatic alternative splicing events in pancreatic ductal adenocarcinoma. Cancer letters, 518, 196-206.

Mallory, M. J., McClory, S. P., Chatrikhi, R., Gazzara, M. R., Ontiveros, R. J., & Lynch, K. W. (2020). Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells. Nucleic acids research, 48(10), 5710-5719.

Wang, L. C., Chen, S. H., Shen, X. L., Li, D. C., Liu, H. Y., Ji, Y. L., ... & Lv, Q. L. (2020). M6A RNA methylation regulator HNRNPC contributes to tumorigenesis and predicts prognosis in glioblastoma multiforme. Frontiers in oncology, 10, 536875.

Huang, G. Z., Wu, Q. Q., Zheng, Z. N., Shao, T. R., Chen, Y. C., Zeng, W. S., & Lv, X. Z. (2020). M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT. Aging (Albany NY), 12(12), 11667.

Wu, Y., Zhao, W., Liu, Y., Tan, X., Li, X., Zou, Q., ... & Yang, X. (2018). Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response. The EMBO journal, 37(23), e99017.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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