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Mouse Anti-HNRNPUL1 Recombinant Antibody (CBFYE-1460) (CBMAB-E2088-FY)

This product is mouse antibody that recognizes HNRNPUL1. The antibody CBFYE-1460 can be used for immunoassay techniques such as: WB, IP.
See all HNRNPUL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYE-1460
Application
WB, IP

Basic Information

Immunogen
Recombinant human protein purified from E.coli
Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.15M NaCl, 0.01% BSA, 50% glycerol
Preservative
0.03% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
heterogeneous nuclear ribonucleoprotein U-like 1
Introduction
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells.
Entrez Gene ID
Human11100
Mouse232989
Rat361522
UniProt ID
HumanQ9BUJ2
MouseQ8VDM6
RatD4A962
Alternative Names
Heterogeneous Nuclear Ribonucleoprotein U Like 1; Adenovirus Early Region 1B-Associated Protein 5; E1B-55 KDa-Associated Protein 5; E1B 55kDa Associated Protein 5; HNRPUL1; E1B-AP5; E1BAP5; Heterogeneous Nuclear Ribonucleoprotein U-Like Protein 1
Function
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.
Biological Process
Response to virus Source: ProtInc
RNA processing Source: ProtInc
Cellular Location
Nucleus
PTM
Methylated.

Long, Y., Ren, Y., Wei, Q., Mobet, Y., Liu, Y., Zhao, H., ... & Yi, P. (2023). NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. International Journal of Medical Sciences, 20(8), 1079.

Yonchev, I. D., Apostol, C. V., Griffith, L., Li, A., Butler, L., Patrick, H., ... & Wilson, S. A. (2023). hnRNPUL1 ensures efficient Integrator-mediated cleavage of snRNAs and is mutated in amyotrophic lateral sclerosis. bioRxiv, 2023-07.

Zhang, M., Zhang, H., Li, Z., Bai, L., Wang, Q., Li, J., ... & Chen, S. J. (2022). Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion. Blood, The Journal of the American Society of Hematology, 140(12), 1390-1407.

Blackwell, D. L., Fraser, S. D., Caluseriu, O., Vivori, C., Tyndall, A. V., Lamont, R. E., ... & Childs, S. J. (2022). Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. G3, 12(5), jkac067.

Li, J., Sang, M., Zheng, Y., Meng, L., Gu, L., Li, Z., ... & Shan, B. (2021). HNRNPUL1 inhibits cisplatin sensitivity of esophageal squamous cell carcinoma through regulating the formation of circMAN1A2. Experimental Cell Research, 409(1), 112891.

Innes, H., Buch, S., Hutchinson, S., Guha, I. N., Morling, J. R., Barnes, E., ... & Stickel, F. (2020). Genome-wide association study for alcohol-related cirrhosis identifies risk loci in MARC1 and HNRNPUL1. Gastroenterology, 159(4), 1276-1289.

Blackwell, D. L., Fraser, S. D., Caluseriu, O., Vivori, C., Gordon, P. M., Tyndall, A. V., ... & Childs, S. J. (2020). Hnrnpul1 loss of function affects skeletal and limb development. bioRxiv, 2020-02.

Romeo, S. (2020). MARC1 and HNRNPUL1: Two Novel Players in Alcohol-related Liver Disease. Gastroenterology, 159(4), 1231-1232.

Zhang, H., Head, P. E., Duong, D. M., Seyfried, N. T., & Yu, D. S. (2019). hnRNPUL1 regulation by ATR in DNA damage response. Cancer Research, 79(13_Supplement), 3452-3452.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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