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Mouse Anti-HOMER3 Recombinant Antibody (9G13) (CBMAB-BR261LY)

The product is antibody recognizes HOMER3. The antibody 9G13 immunoassay techniques such as: FC, WB.
See all HOMER3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9G13
Antibody Isotype
IgG2a
Application
FC: 1-3 μg/1x10 cells, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
E. coli-derived human HOMER3 recombinant protein (Position: R282-A360).
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Preservative
0.05 mg sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homer scaffold protein 3
Introduction
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Entrez Gene ID
9454
UniProt ID
Q9NSC5
Alternative Names
Homer protein homolog 3; Homer-3; HOMER3
Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).
Biological Process
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
Negative regulation of interleukin-2 production Source: UniProtKB
Protein targeting Source: UniProtKB
Regulation of store-operated calcium entry Source: GO_Central
Cellular Location
Cytoplasm; Postsynaptic density; Synapse. Postsynaptic density of neuronal cells.

Mulroy, E., Balint, B., & Bhatia, K. P. (2022). Homer-3 antibody disease: a potentially treatable MSA-C mimic. Movement Disorders Clinical Practice, 9(2), 178-182.

Kuang, Z., Baizabal-Carvallo, J. F., Mofatteh, M., Xie, S., Wang, Z., & Chen, Y. (2022). Anti-homer-3 antibody encephalitis in a 10-year-old child: Case report and review of the literature. Frontiers in Neurology, 13, 929778.

Wu, Q., Gong, B., Jiang, A., & Qin, X. (2022). Case report and literature analysis: Autoimmune cerebellar ataxia associated with homer-3 antibodies. Frontiers in Neurology, 13, 951659.

Miao, A., Yu, C., Sun, Y., Wang, L., Ge, J., & Wang, X. (2022). Acute Cerebellitis associated with anti-Homer 3 antibodies: a rare case report and literature review. Frontiers in Neurology, 13, 837937.

Liu, M., Ren, H., Fan, S., Zhang, W., Xu, Y., Zhao, W., ... & Encephalitis Collaborative Group. (2021). Neurological autoimmunity associated with homer-3 antibody: a case series from China. Neurology-Neuroimmunology Neuroinflammation, 8(6).

Pu, J., Li, W., Wang, A., Zhang, Y., Qin, Z., Xu, Z., ... & Wei, H. (2021). Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages. Cell Death & Disease, 12(12), 1103.

Peixoto, A., Ferreira, D., Azevedo, R., Freitas, R., Fernandes, E., Relvas-Santos, M., ... & Ferreira, J. A. (2021). Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 191.

Liu, Q., He, L., Li, S., Li, F., Deng, G., Huang, X., ... & Lin, C. (2021). HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer. Journal of Hematology & Oncology, 14, 1-16.

Xu, X., Ren, H., Li, L., Wang, J., Fechner, K., & Guan, H. (2019). Anti-Homer-3 antibody associated cerebellar ataxia: a rare case report and literature review. Journal of Neuroimmunology, 330, 155-158.

Son, A., Kang, N., Oh, S. Y., Kim, K. W., Muallem, S., Yang, Y. M., & Shin, D. M. (2019). Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism. Journal of Endocrinology, 242(3), 241-249.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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