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Mouse Anti-HORMAD2 Recombinant Antibody (CBFYH-1721) (CBMAB-H2724-FY)

This product is mouse antibody that recognizes HORMAD2. The antibody CBFYH-1721 can be used for immunoassay techniques such as: WB.
See all HORMAD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1721
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human HORMAD2 produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Horma Domain Containing 2
Introduction
HORMAD2 (HORMA Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is HORMAD1.
Entrez Gene ID
150280
UniProt ID
Q8N7B1
Alternative Names
HORMA Domain Containing 2; HORMA Domain-Containing Protein 2; CT46.2
Function
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).
Biological Process
Meiotic cell cycle Source: UniProtKB
Meiotic sister chromatid cohesion Source: UniProtKB
Cellular Location
Nucleus; Chromosome. Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity).
PTM
Phosphorylated in a SPO11-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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