Rabbit Anti-HOXA1 Recombinant Antibody (EG1541) (CBMAB-EN1840-LY)

Name: Rabbit Anti-HOXA1 Recombinant Antibody (EG1541)
SKU: CBMAB-EN1840-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1541

Application

WB: 1:500~1:1000 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human HOXA1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

homeobox A1

Introduction

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.

Entrez Gene ID

Human	3198
Mouse	15394
Rat	103690132

UniProt ID

Human	P49639
Mouse	P09022
Rat	O08656

Alternative Names

BSAS; HOX1; HOX1F

Function

Sequence-specific transcription factor (By similarity).

Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570).

Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity).

Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).

Biological Process

Abducens nerve formation Source: DFLAT
Anatomical structure morphogenesis Source: DFLAT
Artery development Source: DFLAT
Artery morphogenesis Source: DFLAT
Cochlea development Source: DFLAT
Cochlea morphogenesis Source: DFLAT
Cognition Source: DFLAT
Embryonic neurocranium morphogenesis Source: DFLAT
Inner ear development Source: DFLAT
Multicellular organism development Source: ProtInc
Neuromuscular process Source: DFLAT
Optokinetic behavior Source: DFLAT
Outer ear morphogenesis Source: DFLAT
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of behavior Source: DFLAT
Regulation of transcription by RNA polymerase II Source: GO_Central
Semicircular canal formation Source: DFLAT
Sensory perception of sound Source: DFLAT

Cellular Location

Nucleus

Involvement in disease

Athabaskan brainstem dysgenesis syndrome (ABDS):
Characterized by horizontal gaze palsy, sensorineural deafness, central hypoventilation, and developmental delay. Some patients had swallowing dysfunction, vocal cord paralysis, facial paresis, seizures, and cardiac outflow tract anomalies.
Bosley-Salih-Alorainy syndrome (BSAS):
A disease characterized by horizontal gaze abnormalities, deafness, facial weakness, vascular malformations of the internal carotid arteries and cardiac outflow trac. Some patients manifest mental retardation and autism spectrum disorder. Affected individuals do not suffer from central hypoventilation.

Belpaire, M., Taminiau, A., Geerts, D., & Rezsohazy, R. (2022). HOXA1, a breast cancer oncogene. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1877(4), 188747.

Zhong, W., Bao, L., Yuan, Y., & Meng, Y. (2021). CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis. Bioengineered, 12(1), 3014-3028.

Li, M., Yu, D., Li, Z., Zhao, C., Su, C., & Ning, J. (2021). Long non‑coding RNA AFAP1‑AS1 facilitates the growth and invasiveness of oral squamous cell carcinoma by regulating the miR‑145/HOXA1 axis Retraction in/10.3892/or. 2022.8306. Oncology Reports, 45(3), 1094-1104.

Lyv, X., Wu, F., Zhang, H., Lu, J., Wang, L., & Ma, Y. (2020). Long noncoding RNA ZFPM2-AS1 knockdown restrains the development of retinoblastoma by modulating the MicroRNA-515/HOXA1/Wnt/β-Catenin axis. Investigative ophthalmology & visual science, 61(6), 41-41.

Kim, C. Y., Oh, J. H., Lee, J. Y., & Kim, M. H. (2020). The LncRNA HOTAIRM1 promotes tamoxifen resistance by mediating HOXA1 expression in ER+ breast cancer cells. Journal of Cancer, 11(12), 3416.

Mao, Y., Zhang, L., & Li, Y. (2019). circEIF4G2 modulates the malignant features of cervical cancer via the miR‑218/HOXA1 pathway. Molecular Medicine Reports, 19(5), 3714-3722.

Li, Q., Dong, C., Cui, J., Wang, Y., & Hong, X. (2018). Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme. Journal of Experimental & Clinical Cancer Research, 37(1), 1-15.

Tian, X., Ma, J., Wang, T., Tian, J., Zhang, Y., Mao, L., ... & Wang, S. (2018). Long non-coding RNA HOXA transcript antisense RNA myeloid-specific 1–HOXA1 axis downregulates the immunosuppressive activity of myeloid-derived suppressor cells in lung cancer. Frontiers in immunology, 9, 473.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

HOXA1 Matched Antibody Pair (564) (CAT#: APMAB-564LY)

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HOXA1 Matched Antibody Pair (564) (CAT#: APMAB-564LY)

Mouse Anti-HOXA1 (AA 11-119) Recombinant Antibody (CBFYH-1723) (CAT#: CBMAB-H2726-FY)

Isotype control

For research use only. Not intended for any clinical use.

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