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Mouse Anti-HOXA11 Recombinant Antibody (5A3) (CBMAB-A4011-LY)

The product is antibody recognizes HOXA11. The antibody 5A3 immunoassay techniques such as: WB, ELISA.
See all HOXA11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5A3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXA11 (NP_005514, 60 a.a. ~ 166 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox A11
Introduction
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq]
Entrez Gene ID
3207
Alternative Names
HOX1; HOX1I
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anatomical structure development Source: GO_Central
Anatomical structure morphogenesis Source: ProtInc
Anterior/posterior pattern specification Source: Ensembl
Branching involved in ureteric bud morphogenesis Source: UniProtKB
Cartilage development involved in endochondral bone morphogenesis Source: UniProtKB
Developmental growth Source: UniProtKB
Dorsal/ventral pattern formation Source: UniProtKB
Embryonic digit morphogenesis Source: Ensembl
Embryonic forelimb morphogenesis Source: Ensembl
Embryonic limb morphogenesis Source: UniProtKB
Embryonic skeletal joint morphogenesis Source: Ensembl
Male gonad development Source: Ensembl
Mesodermal cell fate specification Source: UniProtKB
Metanephros development Source: Ensembl
Organ induction Source: Ensembl
Positive regulation of cell development Source: UniProtKB
Positive regulation of chondrocyte differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Prostate gland development Source: Ensembl
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to estrogen Source: Ensembl
Response to testosterone Source: Ensembl
Single fertilization Source: Ensembl
Skeletal system development Source: UniProtKB
Spermatogenesis Source: Ensembl
Uterus development Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 (RUSAT1):
The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation.

Wei, C., Zhao, L., Liang, H., Zhen, Y., & Han, L. (2020). Recent advances in unraveling the molecular mechanisms and functions of HOXA11‑AS in human cancers and other diseases. Oncology reports, 43(6), 1737-1754.

Niu, X., Yang, B., Liu, F., & Fang, Q. (2020). LncRNA HOXA11-AS promotes OSCC progression by sponging miR-98-5p to upregulate YBX2 expression. Biomedicine & Pharmacotherapy, 121, 109623.

Zhang, Y., Yuan, Y., Li, Y., Zhang, P., Chen, P., & Sun, S. (2019). An inverse interaction between HOXA11 and HOXA11-AS is associated with cisplatin resistance in lung adenocarcinoma. Epigenetics, 14(10), 949-960.

Guo, J. C., Yang, Y. J., Zheng, J. F., Zhang, J. Q., Guo, M., Yang, X., ... & Zhuo, L. (2019). Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells. Experimental & molecular medicine, 51(11), 1-20.

Yang, X., Deng, Y., He, R. Q., Li, X. J., Ma, J., Chen, G., & Hu, X. H. (2018). Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches. International journal of molecular medicine, 42(5), 2650-2664.

Xue, J. Y., Huang, C., Wang, W., Li, H. B., Sun, M., & Xie, M. (2018). HOXA11-AS: a novel regulator in human cancer proliferation and metastasis. OncoTargets and therapy, 4387-4393.

Yang, F. Q., Zhang, J. Q., Jin, J. J., Yang, C. Y., Zhang, W. J., Zhang, H. M., ... & Weng, Z. M. (2018). HOXA11‐AS promotes the growth and invasion of renal cancer by sponging miR‐146b‐5p to upregulate MMP16 expression. Journal of cellular physiology, 233(12), 9611-9619.

Zhao, X., Li, X., Zhou, L., Ni, J., Yan, W., Ma, R., ... & Chen, P. (2018). LncRNA HOXA11‐AS drives cisplatin resistance of human LUAD cells via modulating miR‐454‐3p/Stat3. Cancer Science, 109(10), 3068-3079.

Lu, S., Jiang, X., Su, Z., Cui, Z., Fu, W., & Tai, S. (2018). The role of the long non‐coding RNA HOXA11‐AS in promoting proliferation and metastasis of malignant tumors. Cell Biology International, 42(12), 1596-1601.

Qu, L., Jin, M., Yang, L., Sun, C., Wang, P., Li, Y., ... & Sun, Y. (2018). Expression of long non-coding RNA HOXA11-AS is correlated with progression of laryngeal squamous cell carcinoma. American Journal of Translational Research, 10(2), 573.

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For research use only. Not intended for any clinical use.

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