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Mouse Anti-HOXA4 Recombinant Antibody (CBFYH-1734) (CBMAB-H2740-FY)

This product is mouse antibody that recognizes HOXA4. The antibody CBFYH-1734 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all HOXA4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1734
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HOMEOBOX A4
Introduction
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
Entrez Gene ID
3201
UniProt ID
Q00056
Alternative Names
Homeobox A4; Homeobox Protein Hox-1.4; Homeobox Protein Hox-1D; Homeo Box A4; HOX1D; Homeobox Protein Hox-A4; Hox-1.4-Like Protein; Dfd-Like Protein; HOX1
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Aonuma, T., Moukette, B., Kawaguchi, S., Barupala, N. P., Sepúlveda, M. N., Frick, K., ... & Kim, I. M. (2022). MiR-150 attenuates maladaptive cardiac remodeling mediated by long noncoding RNA MIAT and directly represses profibrotic Hoxa4. Circulation: Heart Failure, 15(4), e008686.

Yu, Z., Liu, Z., Lian, X., Cheng, X., Liu, B., Zhang, B., ... & Gao, Y. (2022). High expression of HOXA4 in patients with glioma indicates unfavorable clinical outcomes. Cell Cycle, 21(22), 2387-2402.

Hernández, H. G., Hernández‐Castañeda, A. A., Pieschacón, M. P., & Arboleda, H. (2021). ZNF718, HOXA4, and ZFP57 are differentially methylated in periodontitis in comparison with periodontal health: epigenome‐wide DNA methylation pilot study. Journal of Periodontal Research, 56(4), 710-725.

Bhatlekar, S., Ertel, A., Gonye, G. E., Fields, J. Z., & Boman, B. M. (2019). Gene expression signatures for HOXA4, HOXA9, and HOXD10 reveal alterations in transcriptional regulatory networks in colon cancer. Journal of cellular physiology, 234(8), 13042-13056.

Tang, X., Jiang, J., Zhu, J., He, N., & Tan, J. (2019). HOXA4-regulated miR-138 suppresses proliferation and gefitinib resistance in non-small cell lung cancer. Molecular Genetics and Genomics, 294(1), 85-93.

Miller, K. R., Patel, J. N., Zhang, Q., Norris, E. J., Symanowski, J., Michener, C., ... & Ganapathi, M. K. (2018). HOXA4/HOXB3 gene expression signature as a biomarker of recurrence in patients with high-grade serous ovarian cancer following primary cytoreductive surgery and first-line adjuvant chemotherapy. Gynecologic Oncology, 149(1), 155-162.

Cheng, S., Qian, F., Huang, Q., Wei, L., Fu, Y., & Du, Y. (2018). HOXA4, down-regulated in lung cancer, inhibits the growth, motility and invasion of lung cancer cells. Cell death & disease, 9(5), 465.

Bhatlekar, S., Viswanathan, V., Fields, J. Z., & Boman, B. M. (2018). Overexpression of HOXA4 and HOXA9 genes promotes self‐renewal and contributes to colon cancer stem cell overpopulation. Journal of cellular physiology, 233(2), 727-735.

Elias, M. H., Azlan, H., Sulong, S., Baba, A. A., & Ankathil, R. (2018). Aberrant DNA methylation at HOXA4 and HOXA5 genes are associated with resistance to imatinib mesylate among chronic myeloid leukemia patients. Cancer Reports, 1(2), e1111.

Yu, S., Ren, H., Li, Y., Liang, X., Ning, Q., Chen, X., ... & Hu, T. (2018). HOXA4-dependent transcriptional activation of AXL promotes cisplatin-resistance in lung adenocarcinoma cells. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 18(14), 2062-2067.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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