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Mouse Anti-HOXB1 Recombinant Antibody (1E2) (CBMAB-A4033-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
1E2
Application
WB, ELISA
Immunogen
HOXB1 (NP_002135, 1 a.a. ~ 74 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Homeobox B1
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq]
Entrez Gene ID
3211
UniProt ID
P14653
Alternative Names
HOX2; HOX2I; Hox-2.9; MGC116843; MGC116844; MGC116845
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
Biological Process
Anatomical structure formation involved in morphogenesis Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Facial nerve structural organization Source: Ensembl
Facial nucleus development Source: Ensembl
Pattern specification process Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Rhombomere 4 development Source: Ensembl
Rhombomere 5 development Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Facial paresis, hereditary congenital, 3 (HCFP3):
A form of facial paresis, a disease characterized by isolated dysfunction of the facial nerve (CN VII). HCFP3 patients are affected by bilateral facial palsy, facial muscle weakness of muscles innervated by CN VII, hearing loss, and strabismus.

Chen, C. H., & Behringer, R. R. (2022). Transgenic human HOXB1-9 directs anterior-posterior axial skeleton pattern in Hoxb1-9 deficient mice. Differentiation, 127, 1-11.

Pazur, K., Giannios, I., Lesche, M., Rodriguez-Aznar, E., & Gavalas, A. (2022). Hoxb1 regulates distinct signaling pathways in neuromesodermal and hindbrain progenitors to promote cell survival and specification. Stem Cells, 40(2), 175-189.

Singh, N. P., De Kumar, B., Paulson, A., Parrish, M. E., Scott, C., Zhang, Y., ... & Krumlauf, R. (2021). Genome-wide binding analyses of HOXB1 revealed a novel DNA binding motif associated with gene repression. Journal of developmental biology, 9(1), 6.

Cui, F., Zhou, Q., Xiao, K., & Ma, S. (2020). The microRNA hsa-let-7g promotes proliferation and inhibits apoptosis in lung cancer by targeting HOXB1. Yonsei Medical Journal, 61(3), 210-217.

Zhou, J. L., Deng, S., Fang, H. S., Yu, G., & Peng, H. (2019). Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway. Biomedicine & Pharmacotherapy, 109, 2335-2341.

Zaffran, S., Odelin, G., Stefanovic, S., Lescroart, F., & Etchevers, H. C. (2018). Ectopic expression of Hoxb1 induces cardiac and craniofacial malformations. Genesis, 56(6-7), e23221.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

HOXB1 Matched Antibody Pair (565) (CAT#: APMAB-565LY)

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HOXB1 Matched Antibody Pair (565) (CAT#: APMAB-565LY)

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Mouse Anti-HOXB1 Recombinant Antibody (CBFYH-1755) (CAT#: CBMAB-H0716-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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