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Rabbit Anti-HOXB2 Recombinant Antibody (EG1545) (CBMAB-EN1844-LY)

The product is antibody recognizes HOXB2. The antibody EG1545 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all HOXB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1545
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HOXB2.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Homeobox B2
Introduction
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3212
UniProt ID
P14652
Alternative Names
Homeobox B2; Homeobox Protein Hox-2.8; Homeobox Protein Hox-2H; Homeo Box B2; HOX2H; K8;
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Blood circulation Source: ProtInc
Dorsal/ventral pattern formation Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Facial nerve structural organization Source: Ensembl
Morphogenesis of an epithelial sheet Source: Ensembl
Multicellular organism development Source: ProtInc
Neural nucleus development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Rhombomere 3 development Source: Ensembl
Rhombomere 4 development Source: Ensembl
Cellular Location
Nucleus

Yang, X., Tong, Y., Ye, W., & Chen, L. (2022). HOXB2 increases the proliferation and invasiveness of colon cancer cells through the upregulation of CCT6A. Molecular Medicine Reports, 25(5), 1-9.

Pan, X., Liu, W., Chai, Y., Wang, J., & Zhang, Y. (2020). Genetic and clinical characterization of HOXB2 in glioma. OncoTargets and therapy, 10465-10473.

Xu, F., Liu, Z., Liu, R., Lu, C., Wang, L., Mao, W., ... & Ge, D. (2020). Epigenetic induction of tumor stemness via the lipopolysaccharide-TET3-HOXB2 signaling axis in esophageal squamous cell carcinoma. Cell Communication and Signaling, 18, 1-17.

Yu, H. Y., & Pan, S. S. (2020). MiR-202-5p suppressed cell proliferation, migration and invasion in ovarian cancer via regulating HOXB2. Eur Rev Med Pharmacol Sci, 24(2256-2263).

Zhang, Z., Liang, X., Ren, L., Zhang, S., Li, S., Wan, T., ... & Lv, S. (2020). LINC00662 promotes cell viability and metastasis in esophageal squamous cell carcinoma by sponging miR‐340‐5p and upregulating HOXB2. Thoracic Cancer, 11(8), 2306-2315.

Liu, J., Li, S., Cheng, X., Du, P., Yang, Y., & Jiang, W. G. (2019). HOXB2 is a putative tumour promotor in human bladder cancer. Anticancer Research, 39(12), 6915-6921.

Pan, B., Zhao, M., Wang, N., Xu, L., Wu, T., & Li, Z. (2019). LncRNA RGMB-AS1 promotes glioma growth and invasion through miR-1200/HOXB2 axis. OncoTargets and therapy, 12, 10107.

Chen, X., WU, H., LI, L., & QIU, X. (2019). Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis. Neoplasma, 66(3).

Li, S., Pei, Y., Wang, W., Liu, F., Zheng, K., & Zhang, X. (2019). Circular RNA 0001785 regulates the pathogenesis of osteosarcoma as a ceRNA by sponging miR-1200 to upregulate HOXB2. Cell Cycle, 18(11), 1281-1291.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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