Mouse Anti-HOXB7 (AA 55-121) Recombinant Antibody (CBFYH-1776) (CBMAB-H2786-FY)

Name: Mouse Anti-HOXB7 (AA 55-121) Recombinant Antibody (CBFYH-1776)
SKU: CBMAB-H2786-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-1776

Application

ELISA, IHC-P, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 55-121

More Infomation

Target

Full Name

Homeobox B7

Introduction

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.

Entrez Gene ID

3217

UniProt ID

P09629

Alternative Names

Homeobox B7; Homeobox Protein HHO.C1; Homeobox Protein Hox-2C; Homeo Box B7; HOX2C; Homeobox Protein Hox-B7

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Embryonic organ development Source: UniProtKB
Embryonic skeletal system morphogenesis Source: Ensembl
Myeloid cell differentiation Source: Ensembl
Positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Komatsuda, H., Wakisaka, R., Kono, M., Kumai, T., Hayashi, R., Yamaki, H., ... & Kobayashi, H. (2023). Mitogen‐activated protein kinase inhibition augments the T cell response against HOXB7‐expressing tumor through human leukocyte antigen upregulation. Cancer Science, 114(2), 399.

de Bessa Garcia, S. A., Araújo, M., Pereira, T., & Freitas, R. (2021). HOXB7 overexpression leads triple-negative breast Cancer cells to a less aggressive phenotype. Biomedicines, 9(5), 515.

Casari, G., Resca, E., Giorgini, A., Candini, O., Petrachi, T., Piccinno, M. S., ... & Veronesi, E. (2021). Microfragmented adipose tissue is associated with improved ex vivo performance linked to HOXB7 and b-FGF expression. Stem Cell Research & Therapy, 12(1), 1-13.

Zhou, T., Fu, H., Dong, B., Dai, L., Yang, Y., Yan, W., & Shen, L. (2020). HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair. Thoracic Cancer, 11(11), 3071-3085.

Cheng, W., Shi, X., Lin, M., Yao, Q., Ma, J., & Li, J. (2020). LncRNA MAGI2-AS3 overexpression sensitizes esophageal cancer cells to irradiation through down-regulation of HOXB7 via EZH2. Frontiers in Cell and Developmental Biology, 8, 552822.

Zhang, D. W., Wu, H. Y., Zhu, C. R., & Wu, D. D. (2020). CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma. International Journal of Oncology, 57(2), 478-487.

Dai, L., Hu, W., Yang, Z., Chen, D., He, B., Chen, Y., ... & Zheng, S. (2019). Upregulated expression of HOXB7 in intrahepatic cholangiocarcinoma is associated with tumor cell metastasis and poor prognosis. Laboratory Investigation, 99(6), 736-748.

Foppiani, E. M., Candini, O., Mastrolia, I., Murgia, A., Grisendi, G., Samarelli, A. V., ... & Dominici, M. (2019). Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors. Stem Cell Research & Therapy, 10(1), 1-12.

Monterisi, S., Lo Riso, P., Russo, K., Bertalot, G., Vecchi, M., Testa, G., ... & Bianchi, F. (2018). HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype. Oncogene, 37(26), 3575-3588.

Gao, D., & Chen, H. Q. (2018). Specific knockdown of HOXB7 inhibits cutaneous squamous cell carcinoma cell migration and invasion while inducing apoptosis via the Wnt/β-catenin signaling pathway. American Journal of Physiology-Cell Physiology, 315(5), C675-C686.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

HOXB7 Matched Antibody Pair (566) (CAT#: APMAB-566LY)

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HOXB7 Matched Antibody Pair (566) (CAT#: APMAB-566LY)

Isotype control

For research use only. Not intended for any clinical use.

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