Mouse Anti-HOXC10 Monoclonal Antibody (CBFYH-3193) (CBMAB-H2799-FY)

Name: Mouse Anti-HOXC10 Monoclonal Antibody (CBFYH-3193)
SKU: CBMAB-H2799-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-3193

Application

Dot, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

homeobox C10

Introduction

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.

Entrez Gene ID

3226

UniProt ID

Q9NYD6

Alternative Names

Homeobox C10; Homeobox Protein Hox-3I; Homeo Box C10; HOX3I; Homeobox Protein Hox-C10; Homeoprotein C10

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Neuromuscular process Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal system development Source: Ensembl
Spinal cord motor neuron cell fate specification Source: Ensembl

Cellular Location

Nucleus

Li, Y., Lei, H., Hai, R., Shu, G., Yan, W., & Yin, G. (2022). HOXC10 promotes carboplatin resistance of ovarian cancer by regulating ABCC3. American Journal of Cancer Research, 12(10), 4602.

Chen, Z., Wu, J., Liu, B., Zhang, G., Wang, Z., Zhang, L., ... & Zhu, P. (2021). Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations. Cell Reports, 36(4).

Fang, J., Wang, J., Yu, L., & Xu, W. (2021). Role of HOXC10 in Cancer. Frontiers in Oncology, 11, 684021.

Suo, D., Wang, Z., Li, L., Chen, Q., Zeng, T., Liu, R., ... & Li, Y. (2020). HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis. Oncogene, 39(32), 5441-5454.

Enteghami, M., Ghorbani, M., Zamani, M., & Galehdari, H. (2020). HOXC10 is significantly overexpressed in colorectal cancer. Biomedical reports, 13(3), 1-1.

Dang, Y., Chen, J., Feng, W., Qiao, C., Han, W., Nie, Y., ... & Xia, L. (2020). Interleukin 1β-mediated HOXC10 overexpression promotes hepatocellular carcinoma metastasis by upregulating PDPK1 and VASP. Theranostics, 10(8), 3833.

Peng, Y., Li, Y., Li, Y., Wu, A., Fan, L., Huang, W., ... & Yin, G. (2020). HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer. Aging (Albany NY), 12(19), 19375.

Kim, J., Bae, D. H., Kim, J. H., Song, K. S., Kim, Y. S., & Kim, S. Y. (2019). HOXC10 overexpression promotes cell proliferation and migration in gastric cancer. Oncology reports, 42(1), 202-212.

Dai, B. W., Yang, Z. M., Deng, P., Chen, Y. R., He, Z. J., Yang, X., ... & Ren, Z. H. (2019). HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma. Journal of Cancer, 10(19), 4540.

Tan, Z., Chen, K., Wu, W., Zhou, Y., Zhu, J., Wu, G., ... & Li, J. (2018). Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression. Theranostics, 8(18), 5143.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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