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Mouse Anti-HOXC11 (AA 1-304) Recombinant Antibody (CBFYH-1801) (CBMAB-H2813-FY)

This product is mouse antibody that recognizes HOXC11. The antibody CBFYH-1801 can be used for immunoassay techniques such as: WB, IHC, IF, FC.
See all HOXC11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1801
Antibody Isotype
IgG1
Application
WB, IHC, IF, FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-304 of human HOXC11 produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.44 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-304

Target

Full Name
HOMEOBOX C11
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.
Entrez Gene ID
3227
UniProt ID
O43248
Alternative Names
Homeobox C11; Homeobox Protein Hox-3H; Homeo Box C11; HOX3H; Homeobox Protein Hox-C11
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.
Biological Process
Anatomical structure development Source: GO_Central
Anterior/posterior pattern specification Source: Ensembl
Embryonic digit morphogenesis Source: Ensembl
Embryonic skeletal joint morphogenesis Source: Ensembl
Endoderm development Source: ProtInc
Metanephros development Source: Ensembl
Organ induction Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Peng, X., Liu, X., Hu, W., Zhou, Y., Ouyang, L., Peng, X., ... & Liu, S. (2023). HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1. Cell Death & Disease, 14(2), 153.

Shen, K., Zhang, M., Wang, J., Mu, W., Wang, J., Wang, C., ... & Xiao, M. (2022). Inherited heterozygous Fanconi anemia gene mutations in a therapy-related CMML patient with a rare NUP98-HOXC11 fusion: a case report. Frontiers in Oncology, 12, 1036511.

Varešlija, D., & Young, L. (2022). PAWR as a Direct SRC-1/HOXC11 Suppression Target. Tumor Suppressor Par-4: Structural Features, Molecular Mechanisms and Function, 293-308.

Peng, X., Sun, J., Long, Y., Xiao, D., Zhou, J., Tao, Y., & Liu, S. (2021). The significance of HOXC11 and LSH in survival prediction in gastric adenocarcinoma. OncoTargets and therapy, 1517-1529.

Liu, L., Jia, S., Jin, X., Zhu, S., & Zhang, S. (2021). HOXC11 expression is associated with the progression of colon adenocarcinoma and is a prognostic biomarker. DNA and Cell Biology, 40(9), 1158-1166.

Gong, N., Li, F., Wang, Y., Li, Z., Wang, W., Gong, T., ... & Chen, H. (2021). HOXC11 positively regulates the long non-coding RNA HOTAIR and is associated with poor prognosis in colon adenocarcinoma. Experimental and Therapeutic Medicine, 22(5), 1-6.

Cui, Y., Zhang, C., Wang, Y., Ma, S., Cao, W., & Guan, F. (2020). HOXC11 functions as a novel oncogene in human colon adenocarcinoma and kidney renal clear cell carcinoma. Life sciences, 243, 117230.

Sun, B., Hua, J., Cui, H., Liu, H., Zhang, K., & Zhou, H. (2019). MicroRNA-1197 downregulation inhibits proliferation and migration in human non-small cell lung cancer cells by upregulating HOXC11. Biomedicine & Pharmacotherapy, 117, 109041.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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