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Mouse Anti-HP Recombinant Antibody (CBFYH-1862) (CBMAB-H2870-FY)

This product is mouse antibody that recognizes HP. The antibody CBFYH-1862 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all HP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1862
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
HP was raised against protein purified from human plasma
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Haptoglobin
Introduction
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
3240
UniProt ID
P00738
Alternative Names
Haptoglobin; Zonulin; Haptoglobin, Alpha Polypeptide; Haptoglobin, Beta Polypeptide; Haptoglobin Alpha(2FS)-Beta; Haptoglobin Alpha(1S)-Beta
Function
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Biological Process
Acute inflammatory response Source: GO_Central
Acute-phase response Source: UniProtKB-KW
Defense response Source: ProtInc
Defense response to bacterium Source: UniProtKB-KW
Immune system process Source: UniProtKB-KW
Negative regulation of hydrogen peroxide catabolic process Source: BHF-UCL
Negative regulation of oxidoreductase activity Source: BHF-UCL
Positive regulation of cell death Source: BHF-UCL
Response to hydrogen peroxide Source: BHF-UCL
Zymogen activation Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Anhaptoglobinemia (AHP):
A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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