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Mouse Anti-HP Monoclonal Antibody (CBFYR0664) (CBMAB-R0664-FY)

This product is mouse antibody that recognizes HP.
See all HP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYR0664
Antibody Isotype
IgG1

Basic Information

Immunogen
Human Hemoglobin
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Haptoglobin
Introduction
Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene.[5][6] In blood plasma, haptoglobin binds to free hemoglobin[7], compared to hemopexin that binds to free heme,[8] released from erythrocytes with high affinity and thereby inhibits its oxidative activity.
Entrez Gene ID
3240
UniProt ID
P00738
Alternative Names
HP
Function
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Biological Process
Acute inflammatory response Source: GO_Central
Acute-phase response Source: UniProtKB-KW
Defense response Source: ProtInc
Defense response to bacterium Source: UniProtKB-KW
Immune system process Source: UniProtKB-KW
Negative regulation of hydrogen peroxide catabolic process Source: BHF-UCL
Negative regulation of oxidoreductase activity Source: BHF-UCL
Positive regulation of cell death Source: BHF-UCL
Response to hydrogen peroxide Source: BHF-UCL
Zymogen activation Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Anhaptoglobinemia (AHP):
A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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