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Mouse Anti-HPSE2 Recombinant Antibody (DHIC2-2B4) (CBMAB-H2935-FY)

This product is mouse antibody that recognizes HPSE2. The antibody DHIC2-2B4 can be used for immunoassay techniques such as: WB, FC, IHC, IF, IHC-Fr.
See all HPSE2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
DHIC2-2B4
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IHC-Fr

Basic Information

Immunogen
Human pancreatic enriched alpha cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
heparanase 2
Introduction
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
60495
UniProt ID
Q8WWQ2
Alternative Names
Heparanase 2 (Inactive); HPA2; Heparanase-Like Protein; Inactive Heparanase-2; Urofacial Syndrome; Heparanase 2
Function
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
Biological Process
Extracellular matrix organization Source: Ensembl
Glycosaminoglycan catabolic process Source: Reactome
Positive regulation of cell population proliferation Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Urofacial syndrome 1 (UFS1):
A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.

Buijsers, B., Garsen, M., de Graaf, M., Bakker-van Bebber, M., Guo, C., Li, X., & van der Vlag, J. (2023). Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy. Frontiers in Pharmacology, 14, 1098184.

Kayal, Y., Barash, U., Naroditsky, I., Ilan, N., & Vlodavsky, I. (2023). Heparanase 2 (Hpa2)-a new player essential for pancreatic acinar cell differentiation. Cell Death & Disease, 14(7), 465.

Zhang, H., Xu, C., Shi, C., Zhang, J., Qian, T., Wang, Z., ... & Feng, J. (2021). Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis. Journal of Translational Medicine, 19, 1-13.

Wu, B., Liu, G., Jin, Y., Yang, T., Zhang, D., Ding, L., ... & Wei, Y. (2020). miR-15b-5p promotes growth and metastasis in breast cancer by targeting HPSE2. Frontiers in oncology, 10, 108.

Roberts, N. A., & Woolf, A. S. (2020). Heparanase 2 and urofacial syndrome, a genetic neuropathy. Heparanase: From Basic Research to Clinical Applications, 807-819.

Pinhal, M. A. S., Melo, C. M., & Nader, H. B. (2020). The good and bad sides of heparanase-1 and heparanase-2. Heparanase: From Basic Research to Clinical Applications, 821-845.

Kiyan, Y., Tkachuk, S., Kurselis, K., Shushakova, N., Stahl, K., Dawodu, D., ... & Haller, H. (2019). Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling. Scientific reports, 9(1), 13591.

Roberts, N. A., Hilton, E. N., Lopes, F. M., Singh, S., Randles, M. J., Gardiner, N. J., ... & Woolf, A. S. (2019). Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder. Kidney International, 95(5), 1138-1152.

Vlodavsky, I., Gross-Cohen, M., Weissmann, M., Ilan, N., & Sanderson, R. D. (2018). Opposing functions of heparanase-1 and heparanase-2 in cancer progression. Trends in biochemical sciences, 43(1), 18-31.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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