Mouse Anti-HPSE2 Recombinant Antibody (DHIC2-2B4) (CBMAB-H2935-FY)

Name: Mouse Anti-HPSE2 Recombinant Antibody (DHIC2-2B4)
SKU: CBMAB-H2935-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

DHIC2-2B4

Application

WB, FC, IHC, IF, IHC-Fr

Immunogen

Human pancreatic enriched alpha cells

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

heparanase 2

Introduction

This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.

Entrez Gene ID

60495

UniProt ID

Q8WWQ2

Alternative Names

Heparanase 2 (Inactive); HPA2; Heparanase-Like Protein; Inactive Heparanase-2; Urofacial Syndrome; Heparanase 2

Function

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).

Biological Process

Extracellular matrix organization Source: Ensembl
Glycosaminoglycan catabolic process Source: Reactome
Positive regulation of cell population proliferation Source: Ensembl

Cellular Location

Extracellular matrix

Involvement in disease

Urofacial syndrome 1 (UFS1):
A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure.

Buijsers, B., Garsen, M., de Graaf, M., Bakker-van Bebber, M., Guo, C., Li, X., & van der Vlag, J. (2023). Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy. Frontiers in Pharmacology, 14, 1098184.

Kayal, Y., Barash, U., Naroditsky, I., Ilan, N., & Vlodavsky, I. (2023). Heparanase 2 (Hpa2)-a new player essential for pancreatic acinar cell differentiation. Cell Death & Disease, 14(7), 465.

Zhang, H., Xu, C., Shi, C., Zhang, J., Qian, T., Wang, Z., ... & Feng, J. (2021). Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis. Journal of Translational Medicine, 19, 1-13.

Wu, B., Liu, G., Jin, Y., Yang, T., Zhang, D., Ding, L., ... & Wei, Y. (2020). miR-15b-5p promotes growth and metastasis in breast cancer by targeting HPSE2. Frontiers in oncology, 10, 108.

Roberts, N. A., & Woolf, A. S. (2020). Heparanase 2 and urofacial syndrome, a genetic neuropathy. Heparanase: From Basic Research to Clinical Applications, 807-819.

Pinhal, M. A. S., Melo, C. M., & Nader, H. B. (2020). The good and bad sides of heparanase-1 and heparanase-2. Heparanase: From Basic Research to Clinical Applications, 821-845.

Kiyan, Y., Tkachuk, S., Kurselis, K., Shushakova, N., Stahl, K., Dawodu, D., ... & Haller, H. (2019). Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling. Scientific reports, 9(1), 13591.

Roberts, N. A., Hilton, E. N., Lopes, F. M., Singh, S., Randles, M. J., Gardiner, N. J., ... & Woolf, A. S. (2019). Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder. Kidney International, 95(5), 1138-1152.

Vlodavsky, I., Gross-Cohen, M., Weissmann, M., Ilan, N., & Sanderson, R. D. (2018). Opposing functions of heparanase-1 and heparanase-2 in cancer progression. Trends in biochemical sciences, 43(1), 18-31.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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