Mouse Anti-HPV-16 E7 Recombinant Antibody (CBMW-H0848) (CBMAB-V208-0977-FY)

Name: Mouse Anti-HPV-16 E7 Recombinant Antibody (CBMW-H0848)
SKU: CBMAB-V208-0977-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBMW-H0848

Application

IHC-P, IP, WB

Immunogen

Bacterially derived fusion protein containing the human papillomavirus tp 16 early protein E7 open reading frame

Specificity

HPV

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 1% BSA

Preservative

0.1% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Human Papilloma virus type 16 early protein E7

Introduction

Human papillomavirus is a DNA virus from the papillomavirus family, of which over 150 types are known. More than 40 types are transmitted through sexual contact and infect the anus and genitals. HPV is typically spread by sustained direct skin-to-skin contact with vaginal and anal sex being the most common methods.

Alternative Names

Human Papillomavirus; HPV

Function

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).

Biological Process

Modulation by virus of host G1/S transition checkpoint Source: UniProtKB-UniRule
Modulation by virus of host transcription Source: UniProtKB
Positive regulation by symbiont of host transcription Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity Source: UniProtKB
Suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule

Cellular Location

Host cytoplasm; Host nucleus. Predominantly found in the host nucleus.

PTM

Highly phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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