Mouse Anti-HR (AA 946-1189) Recombinant Antibody (CBFYH-1943) (CBMAB-H2953-FY)

Name: Mouse Anti-HR (AA 946-1189) Recombinant Antibody (CBFYH-1943)
SKU: CBMAB-H2953-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-1943

Application

WB, IHC, IHC-P

Immunogen

Human recombinant protein fragment corresponding to amino acids 946-1189 of human HR produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 946-1189

More Infomation

Target

Full Name

HR, Lysine Demethylase And Nuclear Receptor Corepressor

Introduction

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

55806

UniProt ID

O43593

Alternative Names

HR, Lysine Demethylase And Nuclear Receptor Corepressor; Hair Growth Associated; Lysine-Specific Demethylase Hairless; Hairless Homolog (Mouse); Hairless Homolog; Protein Hairless; EC 1.14.11.-

Function

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle.

Biological Process

Histone H3-K9 demethylation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Alopecia universalis congenita (ALUNC):
A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.
Atrichia with papular lesions (APL):
An autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair.
Hypotrichosis 4 (HYPT4):
An autosomal dominant condition characterized by reduced amount of hair, alopecia, little or no eyebrows, eyelashes or body hair, and coarse, wiry, twisted hair in early childhood.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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