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Mouse Anti-HR (AA 946-1189) Recombinant Antibody (CBFYH-1943) (CBMAB-H2953-FY)

This product is mouse antibody that recognizes HR. The antibody CBFYH-1943 can be used for immunoassay techniques such as: WB, IHC, IHC-P.
See all HR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1943
Antibody Isotype
IgG1
Application
WB, IHC, IHC-P

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 946-1189 of human HR produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 946-1189

Target

Full Name
HR, Lysine Demethylase And Nuclear Receptor Corepressor
Introduction
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
55806
UniProt ID
O43593
Alternative Names
HR, Lysine Demethylase And Nuclear Receptor Corepressor; Hair Growth Associated; Lysine-Specific Demethylase Hairless; Hairless Homolog (Mouse); Hairless Homolog; Protein Hairless; EC 1.14.11.-
Function
Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle.
Biological Process
Histone H3-K9 demethylation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Alopecia universalis congenita (ALUNC):
A rare disorder characterized by loss of hair from the entire body. No hair are present in hair follicles on skin biopsy.
Atrichia with papular lesions (APL):
An autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair.
Hypotrichosis 4 (HYPT4):
An autosomal dominant condition characterized by reduced amount of hair, alopecia, little or no eyebrows, eyelashes or body hair, and coarse, wiry, twisted hair in early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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