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Rabbit Anti-HRH4 Recombinant Antibody (EG1556) (CBMAB-EN1857-LY)

The product is antibody recognizes HRH4. The antibody EG1556 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:1000.
See all HRH4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1556
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HRH4.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Histamine Receptor H4
Introduction
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Entrez Gene ID
59340
UniProt ID
Q9H3N8
Alternative Names
Histamine Receptor H4; G-Protein Coupled Receptor 105; Pfi-013; GPCR105; AXOR35; GPRv53; SP9144;
Function
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Inflammatory response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: InterPro
Regulation of MAPK cascade Source: InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-52
Helical: 53-73
Extracellular: 74-87
Helical: 88-108
Cytoplasmic: 109-131
Helical: 132-152
Extracellular: 153-172
Helical: 173-193
Cytoplasmic: 194-304
Helical: 305-325
Extracellular: 326-341
Helical: 342-362
Cytoplasmic: 363-390

Ma, X., Verweij, E. W., Siderius, M., Leurs, R., & Vischer, H. F. (2021). Identification of TSPAN4 as novel histamine H4 receptor interactor. Biomolecules, 11(8), 1127.

Savelieva, O. N., Karunas, A. S., Fedorova, Y. Y., Gatiyatullin, R. F., Etkina, E. I., & Khusnutdinova, E. K. (2021). Analysis of association between histamine receptor gene HRH1, HRH2, HRH3, HRH4 polymorphisms and asthma in children. PULMONOLOGIYA, 31(6), 729-738.

Lee, B. J., Byeon, H. E., Cho, C. S., Kim, Y. H., Kim, J. H., Che, J. H., ... & Lee, K. (2020). Histamine causes an imbalance between pro-angiogenic and anti-angiogenic factors in the retinal pigment epithelium of diabetic retina via H4 receptor/p38 MAPK axis. BMJ Open Diabetes Research and Care, 8(2), e001710.

Kordulewska, N., Cieślińska, A., Fiedorowicz, E., Jarmołowska, B., & Kostyra, E. (2019). Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy–in vitro study Short communication. Journal of Pharmacy & Pharmaceutical Sciences, 22, 93-97.

Zhao, Y. X., Pan, J. B., Wang, Y. N., Zou, Y., Guo, L., Tang, Q. Q., & Qian, S. W. (2019). Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue. American Journal of Physiology-Endocrinology and Metabolism, 317(6), E1158-E1171.

Qin, D., Zhang, H., Wang, J., & Hong, Z. (2019). Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease. BMC Medical Genomics, 12(1), 1-7.

Abiuso, A. M. B., Varela, M. L., Durand, L. H., Moreno, M. B., Marcos, A., Ponzio, R., ... & Mondillo, C. (2018). Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys. European Journal of Cancer, 91, 125-135.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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