Rabbit Anti-HRH4 Recombinant Antibody (EG1556) (CBMAB-EN1857-LY)

Name: Rabbit Anti-HRH4 Recombinant Antibody (EG1556)
SKU: CBMAB-EN1857-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1556

Application

IF: 1:100~1:500 ELISA: 1:1000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human HRH4.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Histamine Receptor H4

Introduction

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Entrez Gene ID

59340

UniProt ID

Q9H3N8

Alternative Names

Histamine Receptor H4; G-Protein Coupled Receptor 105; Pfi-013; GPCR105; AXOR35; GPRv53; SP9144;

Function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).

Biological Process

Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Inflammatory response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: InterPro
Regulation of MAPK cascade Source: InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-52
Helical: 53-73
Extracellular: 74-87
Helical: 88-108
Cytoplasmic: 109-131
Helical: 132-152
Extracellular: 153-172
Helical: 173-193
Cytoplasmic: 194-304
Helical: 305-325
Extracellular: 326-341
Helical: 342-362
Cytoplasmic: 363-390

Ma, X., Verweij, E. W., Siderius, M., Leurs, R., & Vischer, H. F. (2021). Identification of TSPAN4 as novel histamine H4 receptor interactor. Biomolecules, 11(8), 1127.

Savelieva, O. N., Karunas, A. S., Fedorova, Y. Y., Gatiyatullin, R. F., Etkina, E. I., & Khusnutdinova, E. K. (2021). Analysis of association between histamine receptor gene HRH1, HRH2, HRH3, HRH4 polymorphisms and asthma in children. PULMONOLOGIYA, 31(6), 729-738.

Lee, B. J., Byeon, H. E., Cho, C. S., Kim, Y. H., Kim, J. H., Che, J. H., ... & Lee, K. (2020). Histamine causes an imbalance between pro-angiogenic and anti-angiogenic factors in the retinal pigment epithelium of diabetic retina via H4 receptor/p38 MAPK axis. BMJ Open Diabetes Research and Care, 8(2), e001710.

Kordulewska, N., Cieślińska, A., Fiedorowicz, E., Jarmołowska, B., & Kostyra, E. (2019). Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy–in vitro study Short communication. Journal of Pharmacy & Pharmaceutical Sciences, 22, 93-97.

Zhao, Y. X., Pan, J. B., Wang, Y. N., Zou, Y., Guo, L., Tang, Q. Q., & Qian, S. W. (2019). Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue. American Journal of Physiology-Endocrinology and Metabolism, 317(6), E1158-E1171.

Qin, D., Zhang, H., Wang, J., & Hong, Z. (2019). Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease. BMC Medical Genomics, 12(1), 1-7.

Abiuso, A. M. B., Varela, M. L., Durand, L. H., Moreno, M. B., Marcos, A., Ponzio, R., ... & Mondillo, C. (2018). Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys. European Journal of Cancer, 91, 125-135.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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