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Mouse Anti-HS2ST1 Recombinant Antibody (CBFYH-1975) (CBMAB-H2986-FY)

This product is mouse antibody that recognizes HS2ST1. The antibody CBFYH-1975 can be used for immunoassay techniques such as: WB.
See all HS2ST1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1975
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1, Met59-Asn356
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
heparan sulfate 2-O-sulfotransferase 1
Introduction
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
Entrez Gene ID
9653
UniProt ID
Q7LGA3
Alternative Names
Heparan Sulfate 2-O-Sulfotransferase 1; 2-O-Sulfotransferase; 2OST; EC 2.8.2.-; DJ604K5.2; KIAA0448; EC 2.8.2; HS2ST
Function
Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity).
Biological Process
Glycosaminoglycan biosynthetic process Source: Reactome
Heparan sulfate proteoglycan biosynthetic process, enzymatic modification Source: GO_Central
Heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process Source: GO_Central
Cellular Location
Golgi apparatus membrane
Involvement in disease
Neurofacioskeletal syndrome with or without renal agenesis (NFSRA):
An autosomal recessive syndrome characterized by developmental delay and/or intellectual disability, corpus callosum agenesis or hypoplasia, flexion contractures, brachydactyly of hands and feet with broad fingertips and toes, and dysmorphic features such as coarse face, upslanted palpebral fissures, broad nasal tip and wide mouth. Some patients manifest unilateral or bilateral renal agenesis.
Topology
Cytoplasmic: 1-11
Helical: 12-28
Lumenal: 29-356
PTM
N-glycosylated.

Yang, G., Jiang, J., Yin, R., Li, Z., Li, L., Gao, F., ... & Zhan, X. (2022). Two novel predictive biomarkers for osteosarcoma and glycolysis pathways: A profiling study on HS2ST1 and SDC3. Medicine, 101(36), e30192.

Berillo, O., Ouerd, S., Idris-Khodja, N., Rehman, A., Richer, C., Sinnett, D., ... & Schiffrin, E. L. (2021). Chromosome 2 Fragment substitutions in dahl salt-sensitive rats and RNA sequencing identified Enpep and Hs2st1 as vascular inflammatory modulators. Hypertension, 77(1), 178-189.

Ahronian, L. G., Fenoglio, S., Das, N., Aird, D., Guerin, D., Whittington, D., ... & Sjin, R. T. T. (2021). Abstract P146: Loss of HS2ST1 cooperates with MAPK inhibition to impair growth of mesenchymal KRAS mutant NSCLC. Molecular Cancer Therapeutics, 20(12_Supplement), P146-P146.

Teixeira, F. C., Vijaya Kumar, A., Kumar Katakam, S., Cocola, C., Pelucchi, P., Graf, M., ... & Götte, M. (2020). The heparan sulfate sulfotransferases HS2ST1 and HS3ST2 are novel regulators of breast cancer stem-cell properties. Frontiers in Cell and Developmental Biology, 8, 559554.

Vijaya Kumar, A., Brézillon, S., Untereiner, V., Sockalingum, G. D., Kumar Katakam, S., Mohamed, H. T., ... & Götte, M. (2020). HS2ST1‐dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior. Cancer Science, 111(8), 2907-2922.

Schneeberger, P. E., von Elsner, L., Barker, E. L., Meinecke, P., Marquardt, I., Alawi, M., ... & Kutsche, K. (2020). Bi-allelic pathogenic variants in HS2ST1 cause a syndrome characterized by developmental delay and corpus callosum, skeletal, and renal abnormalities. The American Journal of Human Genetics, 107(6), 1044-1061.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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