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Mouse Anti-HS6ST1 (AA 303-401) Recombinant Antibody (CBFYH-1982) (CBMAB-H2993-FY)

This product is mouse antibody that recognizes HS6ST1. The antibody CBFYH-1982 can be used for immunoassay techniques such as: ELISA, WB.
See all HS6ST1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1982
Antibody Isotype
IgM, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: IRPFMQYNST RAGGVEVDED TIRRIEELND LDMQLYDYAK DLFQQRYQYK RQLERREQRL RSREERLLHR AKEALPREDA DEPGRVPTED YMSHIIEKW
Specificity
Human
Antibody Isotype
IgM, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 303-401

Target

Full Name
heparan sulfate 6-O-sulfotransferase 1
Introduction
The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.
Entrez Gene ID
9394
UniProt ID
O60243
Alternative Names
Heparan Sulfate 6-O-Sulfotransferase 1; HS6ST-1; HS6ST; Heparan-Sulfate 6-O-Sulfotransferase 1; Heparan-Sulfate 6-Sulfotransferase; EC 2.8.2.-; EC 2.8.2; HH15
Function
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.
Biological Process
Angiogenesis Source: Ensembl
Glycosaminoglycan biosynthetic process Source: Reactome
Heparan sulfate proteoglycan biosynthetic process, enzymatic modification Source: GO_Central
Labyrinthine layer blood vessel development Source: Ensembl
Lung alveolus development Source: Ensembl
Neuron development Source: UniProtKB
Cellular Location
Membrane
Involvement in disease
Hypogonadotropic hypogonadism 15 with or without anosmia (HH15):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Topology
Cytoplasmic: 11-17
Helical: 18-37
Lumenal: 38-411
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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