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Mouse Anti-HSBP1 Recombinant Antibody (CBMAB-BR262LY)

The product is antibody recognizes HSBP1. The antibody immunoassay techniques such as: IF, IHC, WB.
See all HSBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Antibody Isotype
IgG
Application
IF: 1:1000 dilution, IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
Recombinant full length human HSP27 from E. coli.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
5mM sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Heat shock factor-binding protein 1
Introduction
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3281
UniProt ID
O75506
Alternative Names
Heat shock factor-binding protein 1;Nasopharyngeal carcinoma-associated antigen 13;NPC-A-13;HSBP1;HSF1BP;
Function
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Biological Process
Axonal transport of mitochondrion Source: ARUK-UCL
Cellular heat acclimation Source: GO_Central
Endodermal cell differentiation Source: Ensembl
Muscle contraction Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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