Rabbit Anti-EIF3L Recombinant Antibody (EG1605) (CBMAB-EN1919-LY)

Name: Rabbit Anti-EIF3L Recombinant Antibody (EG1605)
SKU: CBMAB-EN1919-LY
Rating: 5 (1 reviews)

See all EIF3L antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1605

Application

WB: 1:500~1:1000 ELISA: 1:1000

Immunogen

The antibody was produced against synthesized peptide derived from N-terminal of human IF3EI.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

eukaryotic translation initiation factor 3 subunit L

Entrez Gene ID

Human	51386
Mouse	223691

UniProt ID

Human	Q9Y262
Mouse	Q8QZY1

Alternative Names

EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP

Research Area

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).

The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).

The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Biological Process

Formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
Translational initiation Source: UniProtKB
Viral translational termination-reinitiation Source: UniProtKB

Cellular Location

Cytoplasm

Cui, L., Liu, M., Lai, S., Hou, H., Diao, T., Zhang, D., ... & Wang, J. (2019). Androgen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells. OncoTargets and therapy, 12, 4451.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-EIF3L Recombinant Antibody (EG1605)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-EIF3L Recombinant Antibody (EG1605) (CAT#: V2LY-0425-LY1706)

Related Products

Mouse Anti-EIF3L Recombinant Antibody (EG1605) (CAT#: V2LY-0425-LY1706)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry