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Mouse Anti-IFNGR1 Recombinant Antibody (CBWJC-3794) (CBMAB-C5062WJ)

This product is a Mouse antibody that recognizes IFNGR1. This antibody CBWJC-3794 can be used for immunoassay techniques such as: ELISA, FC, IHC, WB.
See all IFNGR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3794
Antibody Isotype
IgG2a
Application
ELISA, FC, IHC, WB

Basic Information

Immunogen
Fusion protein of the extracellular part of the human interferon-gamma receptor (aaAla17-Gly245) to 11AA of the c-myc proto-oncogene
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
interferon gamma receptor 1
Introduction
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3459
UniProt ID
P15260
Alternative Names
CD119; IFNGR; IMD27A; IMD27B

Chen, Q., Zhuang, S., Hong, Y., Yang, L., Guo, P., Mo, P., ... & Yu, C. (2022). Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling. Oncogene, 41(10), 1421-1433.

Cheng, L., Zhang, F., Wang, Y., Chen, J., & Yuan, X. (2022). Association between IFNGR1 gene polymorphisms and tuberculosis susceptibility: A meta-analysis. Frontiers in Public Health, 10, 976221.

Du, W., Hua, F., Li, X., Zhang, J., Li, S., Wang, W., ... & Zou, W. (2021). Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal sorting and degradation. Cancer discovery, 11(7), 1826-1843.

Ortiz Fernandez, L., Coit, P., Yilmaz, V., Yentür, S. P., Alibaz‐Oner, F., Aksu, K., ... & Sawalha, A. H. (2021). Genetic Association of a Gain‐of‐Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet’s Disease. Arthritis & Rheumatology, 73(7), 1244-1252.

Singh, S., Kumar, S., Srivastava, R. K., Nandi, A., Thacker, G., Murali, H., ... & Chakrabarti, R. (2020). Loss of ELF5–FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. Nature cell biology, 22(5), 591-602.

Wang, Y., Niu, H., Liu, Y., Yang, H., Zhang, M., & Wang, L. (2020). Promoting effect of long non-coding RNA SNHG1 on osteogenic differentiation of fibroblastic cells from the posterior longitudinal ligament by the microRNA-320b/IFNGR1 network. Cell Cycle, 19(21), 2836-2850.

Wu, S., Liu, X., Wang, Y., Zhang, M., Wang, M., & He, J. Q. (2019). Genetic polymorphisms of IFNG and IFNGR1 with latent tuberculosis infection. Disease Markers, 2019.

Wu, S., Wang, Y., Zhang, M., Wang, M., & He, J. Q. (2019). Genetic variants in IFNG and IFNGR1 and tuberculosis susceptibility. Cytokine, 123, 154775.

Yoo, I., Seo, H., Choi, Y., Jang, H., Han, J., Lee, S., ... & Ka, H. (2019). Analysis of interferon‐γ receptor IFNGR1 and IFNGR2 expression and regulation at the maternal‐conceptus interface and the role of interferon‐γ on endometrial expression of interferon signaling molecules during early pregnancy in pigs. Molecular Reproduction and Development, 86(12), 1993-2004.

Khanolkar, A., Kirschmann, D. A., Caparelli, E. A., Wilks, J. D., Cerullo, J. M., Bergerson, J. R., ... & Fuleihan, R. L. (2018). CD4 T cell–restricted IL-2 signaling defect in a patient with a novel IFNGR1 deficiency. Journal of Allergy and Clinical Immunology, 141(1), 435-439.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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